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Exome sequencing of plasma DNA portrays the mutation landscape of colorectal cancer and discovers mutated VEGFR2 receptors as modulators of antiangiogenic therapies
ArticleAbstract: Purpose: Despite the wide use of antiangiogenic drugs in the clinical setting, pbkp_redictive biomarPalabras claves:Autores:Albarran M.I., Alvarez R., Banos N., Blanco-Aparicio C., Camacho-Artacho M., Cubillo A., De Martino A., Domínguez O., Durán Y., Garralda E., Hidalgo M., Lietha D., Martínez-Torrecuadrada J.L., Mitsi M., Monsech J., Otero A., Perea S., Pons T., Sanchez-Perez T., Sarno F., Toledo R.A., Vega E., Victoria Maritza Cevallos BonillaFuentes:scopusStructures of a bi-functional Kunitz-type STI family inhibitor of serine and aspartic proteases: Could the aspartic protease inhibition have evolved from a canonical serine protease-binding loop?
ArticleAbstract: Bi-functional inhibitors from the Kunitz-type soybean trypsin inhibitor (STI) family are glycosylatePalabras claves:Aspartic protease inhibitors, Bi-functional inhibitors, Kunitz-type STI family inhibitors, Plant protease inhibitors, β-Trefoil foldAutores:Berry C., Pons T., Rudino-Pinera E., Valiente P.A., Yasel GuerraFuentes:googlescopus