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A metabolic perspective of late onset Alzheimer's disease
ReviewAbstract: After decades of research, the molecular neuropathology of Alzheimer's disease (AD)is still one of tPalabras claves:Alzheimer's disease, c-Jun N-terminal kinase inhibitors, Insulin, Licochalcone A, neuroinflammation, Reticulum stress, Type 2 Diabetes mellitusAutores:Antoni Camins, Auladell C., Busquets O., Cano A., Castro-Torres R.D., Ettcheto M., Folch J., García M.L., Manzine P.R., Olloquequi J., Sanchez-Lopez E., Verdaguer E., Zárate C.B.Fuentes:scopusA novel rhein-huprine hybrid ameliorates disease-modifying properties in preclinical mice model of Alzheimer’s disease exacerbated with high fat diet
ArticleAbstract: Background: Alzheimer’s disease (AD) is characterized by a polyetiological origin. Despite the globaPalabras claves:Alzheimer’s disease, BACE1, BDNF, cognitive decline, dendritic spines, high-fat diet, neuroinflammation, Rhein-huprine hybrid, Tau, TLR4Autores:Antoni Camins, Auladell C., Bulló M., Cano A., Espinosa-Jimenez T., Ettcheto M., Folch J., Muñoz-Torrero D., Olloquequi J., Parcerisas A., Pont C., Sanchez-Lopez E., Verdaguer E.Fuentes:scopusADAM10 in Alzheimer's disease: Pharmacological modulation by natural compounds and its role as a peripheral marker
ReviewAbstract: Alzheimer's disease (AD) represents a global burden in the economics of healthcare systems. Amyloid-Palabras claves:ADAM10, Alzheimer's disease, Natural compounds, Pharmaceutical, α-SecretaseAutores:Antoni Camins, Busquets O., Cano A., Cominetti M.R., Di Luca M., Endres K., Ettcheto M., Manzine P.R., Marcello E., Olloquequi J., Pelucchi S.Fuentes:scopusDexibuprofen ameliorates peripheral and central risk factors associated with Alzheimer’s disease in metabolically stressed APPswe/PS1dE9 mice
ArticleAbstract: Background: Several studies stablished a relationship between metabolic disturbances and Alzheimer´sPalabras claves:Alzheimer´s disease, APPswe/PS1dE9, Cognitive deficits, Dexibuprofen, High fat diet, Metabolic alterations, neuroinflammation, synapsis, unfolded protein response, βA plaquesAutores:Antoni Camins, Auladell C., Busquets O., Cano A., Carrasco M., Espinosa-Jimenez T., Ettcheto M., Folch J., Herrera K., Manzine P.R., Olloquequi J., Sanchez-Lopez E., Verdaguer E.Fuentes:scopusEpigallocatechin-3-Gallate (EGCG) Improves Cognitive Deficits Aggravated by an Obesogenic Diet Through Modulation of Unfolded Protein Response in APPswe/PS1dE9 Mice
ArticleAbstract: Epigallocatechin-3-gallate (EGCG), a catechin found in green tea, has been previously investigated fPalabras claves:APPswe/PS1dE9 mice, Cognitive deficits, Epigallocatechin-3-gallate, hippocampus, obesity, unfolded protein responseAutores:Antoni Camins, Auladell C., Busquets O., Cano A., Castro-Torres R.D., Ettcheto M., Folch J., García M.L., Manzine P.R., Olloquequi J., Verdaguer E., Zárate C.B.Fuentes:scopusExperimental models for aging and their potential for novel drug discovery
ReviewAbstract: Background: An interesting area of scientific research is the development of potential antiaging druPalabras claves:aging, Heterogeneous mice model, IGF-1, mTOR, Resveratrol, SAMP8, SirtuinsAutores:Antoni Camins, Auladell C., Busquets O., Casadesús G., Ettcheto M., Folch J., Miguel Marin, Olloquequi J., Pallás M., Sanchez-Lopez E., Zárate C.B.Fuentes:scopusEarly Preclinical Changes in Hippocampal CREB-Binding Protein Expression in a Mouse Model of Familial Alzheimer’s Disease
ArticleAbstract: The molecular basis of memory loss in Alzheimer’s disease (AD), the main cause of senile dementia, iPalabras claves:Alzheimer disease, APPswe/PS1dE9, CBP, CREB, hippocampusAutores:Abad S., Antoni Camins, Auladell C., Busquets O., Carro E., Casadesús G., Ettcheto M., Folch J., Olloquequi J., Pallás M., Pedros I., Petrov D., Sanchez-Lopez E., Zárate C.B.Fuentes:scopusNeuroprotective Effects of the Absence of JNK1 or JNK3 Isoforms on Kainic Acid-Induced Temporal Lobe Epilepsy-Like Symptoms
ArticleAbstract: The activation of c-Jun-N-terminal kinases (JNK) pathway has been largely associated with the pathogPalabras claves:c-Jun N-terminal kinase, Excitotoxicity, hippocampus, inflammation, Kainic acid, Knockout mice, Neurodegeneration, neuroprotectionAutores:Antoni Camins, Auladell C., Castro-Torres R.D., De Lemos M.L., Folch J., Junyent F., Olloquequi J., Verdaguer E., Zárate C.B.Fuentes:scopusPeroxisomal Proliferator-Activated Receptor β/δ Deficiency Induces Cognitive Alterations
ArticleAbstract: Peroxisome proliferator-activated receptor β/δ (PPARβ/δ), the most PPAR abundant isotype in the centPalabras claves:dendritic spines, high-fat diet, insulin signaling, Memory impairment, neuroinflammation, PPARβ/δ, synapsis, T2DMAutores:Antoni Camins, Auladell C., Busquets O., Cano A., Espinosa-Jimenez T., Ettcheto M., Folch J., Olloquequi J., Parcerisas A., Sanchez-Lopez E., Vázquez-Carrera M., Verdaguer E., Wahli W.Fuentes:scopusPharmacological Strategies to Improve Dendritic Spines in Alzheimer's Disease
ReviewAbstract: To deeply understand late onset Alzheimer's disease (LOAD), it may be necessary to change the concepPalabras claves:BDNF, dendritic spines, late onset Alzheimer's disease, neuroinflammation, obesity, Type 2 Diabetes mellitusAutores:Antoni Camins, Auladell C., Busquets O., Cano A., Casadesús G., Castro-Torres R.D., Espinosa-Jimenez T., Ettcheto M., Folch J., Manzine P.R., Olloquequi J., Sanchez-Lopez E., Sureda F.X., Verdaguer E.Fuentes:scopus