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Bio-analytical method based on MALDI-MS analysis for the quantification of CIGB-300 anti-tumor peptide in human plasma
ArticleAbstract: A fully validated bio-analytical method based on Matrix-Assisted-Laser-Desorption/Ionization-Time ofPalabras claves:Anti-tumor peptide, Bio-analytical method, Full validation, Human plasma, Maldi-tofAutores:Audain E., B. G. De la Torre, Besada-Pérez V., Cabrales-Rico A., Garay H.E., Gómez J.A., González L.J., Machado Y.J., Marcelo J.L., Morales O., Perea-Rodríguez S.E., Perera Y., Reyes O., Reyes V.Fuentes:scopusDevelopment and validation of a bioanalytical LC-MS method for the quantification of GHRP-6 in human plasma
ArticleAbstract: Growth hormone-releasing peptide 6 (GHRP-6, His-(DTrp)-Ala-Trp-(DPhe)-Lys-NH 2, MW=872.44Da) is a poPalabras claves:GHRP-6, internal standard, LC-MS, Method validation, PlasmaAutores:Besada-Pérez V., Betancourt L., Cabrales A., García G., Gil J., González L.J., Moya G., Padrón G., Reyes O., Sánchez A., Vivian Morera CórdovaFuentes:scopusDevelopment of new methods to study the amino terminal peptide of proteins and their applications in the biotechnological industry
ArticleAbstract:Palabras claves:Autores:Álvarez F., Besada-Pérez V., Betancourt L., De Cossio J.F., García Y., Gil J., González L.J., Moya G., Padrón G., Ramos Y., Sánchez A., Solano Y., Vivian Morera CórdovaFuentes:scopusCIGB-300, a novel proapoptotic peptide that impairs the CK2 phosphorylation and exhibits anticancer properties both in vitro and in vivo
ArticleAbstract: Protein Kinase CK2 is a serine-threonine kinase frequently deregulated in many human tumors. Here, wPalabras claves:apoptosis, Cancer targeted therapy, Casein kinase 2Autores:Acevedo B.E., Alonso D.F., Ariosa J., Bacardí D.M., Baladron I., Besada-Pérez V., Betancourt L., Castellanos L.R., Cosme K., Cruz M., Díaz A., Falcón-Cama V., Farina H., Garay H.E., Gil J., Gómez D., Gómez R., González L.J., Hernández I., Herrera L., López C., López-Mola E., López-Saura P.A., Marcelo J.L., Mendoza O., Perea-Rodríguez S.E., Perera Y., Puchades Y., Reyes O., Rodriguez A., Sánchez A., Santana A., Serrano J.M., Sigman H., Silva R., Solares M., Thelvia I. Ramos Gómez, Valenzuela-Silva C.M.Fuentes:googlescopusExpression in Escherichia coli of the IpdA gene, protein sequence analysis and immunological characterization of the P64k protein from Neisseria meningitidis
ArticleAbstract: By making use of recombinant DNA technology it is possible to characterize meningococcal outer membrPalabras claves:Autores:Alvarez A., Besada-Pérez V., Caballero E., Carmenate T., Coizeau E., Estrada R., González L.J., González S., Guillén-Nieto G.E., Herrera L., Musacchio Lasa A., Nazabal C., Padrón G., Silva R., Támbara Y., Vivian Morera CórdovaFuentes:scopusOptimizing CIGB-300 intralesional delivery in locally advanced cervical cancer
ArticleAbstract: Background:We conducted a phase 1 trial in patients with locally advanced cervical cancer by injectiPalabras claves:B23/nucleophosmin, Cervical Cancer, CIGB-300, tumour uptakeAutores:Acevedo B.E., Alonso D.F., Ancízar J.A., Baladron I., Casacó C.A., Coca M.A., García I., Gómez R., González L.J., González Y.M., Hernández I., I. Howland-Álvarez, López-Saura P.A., Martínez Y.M., Molina L., Perea-Rodríguez S.E., Perera A., Perera Y., Prats A., Reyes V., Solares M., Torres L.A., Valenzuela-Silva C.M.Fuentes:scopusMolecular characterization of recombinant human interferon alpha-2b produced in Cuba
ArticleAbstract: The recombinant human interferon α 2b (IFN-γ(2b)) produced by Cuban technology is obtained from EschPalabras claves:IFN, Molecular characterization, Recombinant human interferon alfa 2bAutores:Beldarrain A., Besada-Pérez V., Betancourt L., Brito R., Curras T., Eugenio Hardy, Ferrero J., Gil M., González L.J., Herrera L., Huerta V., Martinez E., Moya G., Pujols V., Sanchez J.C., Santana-Milián H., Sosa R., Vivian Morera CórdovaFuentes:googlescopusIsolation and characterization of modified species of a mutated (Cys<sup>125</sup>-Ala) recombinant human interleukin-2
ArticleAbstract: During purification of recombinant and mutated interleukin-2 (rhIL-2A125) by reversed-phase-high-perPalabras claves:interleukins, PeptidesAutores:Araña M.J., Breña F., García Y., González L.J., Huerta V., Moya G., Pérez D., Vivian Morera CórdovaFuentes:scopusSelective isolation and identification of N-terminal blocked peptides from tryptic protein digests
ArticleAbstract: A method for the easy isolation and direct sequencing of N-terminally blocked peptide in proteins rePalabras claves:Acetylated, Ion-exchange, Mass-spectrometry, N-terminal-blocked, Peptide-isolationAutores:Besada V., Betancourt L., González L.J., Padrón G., Shimonishi Y., Takao T., Vivian Morera CórdovaFuentes:scopusPrimary structure of two cytolysin isoforms from Stichodactyla helianthus differing in their hemolytic activity
ArticleAbstract: Sticholysin I (St-I) and sticholysin II (St-II) are cytolysins purified from the sea anemone StichodPalabras claves:Cytolysin, Primary structure, Sea anemone, Secondary structure pbkp_redictionAutores:Álvarez C., Besada-Pérez V., Betancourt L., Chinea G., González L.J., Guanche Y., Huerta V., Lanio M.E., Martínez D., Vivian Morera CórdovaFuentes:scopus