Mostrando 6 resultados de: 6
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Journal of Clinical Endocrinology and Metabolism(2)
Endocrine Research(1)
Journal of Pediatric Endocrinology and Metabolism(1)
Molecular Endocrinology(1)
Steroids(1)
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Enfermedades(3)
Fisiología humana(3)
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Ginecología, obstetricia, pediatría, geriatría(1)
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scopus(6)
Enzymatic activities of P450c17 stably expressed in fibroblasts from patients with the polycystic ovary syndrome
ArticleAbstract: Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting approximately 5-10% of womPalabras claves:Autores:Arlt W., Dunaif A., Geller D.H., Martens J.W.M., Miller W.L., Ossovskaya V.S., Richard J. Auchus, Rodriguez H.Fuentes:scopusP450c17 mutations R347H and R358Q selectively disrupt 17,20-lyase activity by disrupting interactions with P450 oxidoreductase and cytochrome b<inf>5</inf>
ArticleAbstract: Cytochrome P450c17 catalyzes steroid 17α-hydroxylase and 17,20-lyase activities and hence is a key ePalabras claves:Autores:Geller D.H., Miller W.L., Richard J. AuchusFuentes:scopusPitfalls in characterizing P450c17 mutations associated with isolated 17,20-lyase deficiency
ArticleAbstract: The cytochrome P450c17 enzyme system performs both the 17α-hydroxylase and 17,20-lyase reactions inPalabras claves:Autores:Geller D.H., Gupta M.K., Richard J. AuchusFuentes:scopusProbing structural and functional domains of human P450c17
Conference ObjectAbstract: Human P450c17 performs at least six chemical transformations, but this spectrum of activity is diffePalabras claves:Autores:Geller D.H., Miller W.L., Richard J. Auchus, Worthy K.Fuentes:scopusThe function and roles of P450c17 in androgen excess states
Conference ObjectAbstract: Cytochrome P450c17 is a multifunctional enzyme that converts C21 steroids to the C19 sex steroid prePalabras claves:17,20-Lyase, 17-Hydroxylase, 3β-Hydroxysteroid dehydrogenase/Δ(5/4)-isomerase, adrenarche, Dehydroepiandrosterone, P450c17, Polycystic ovary syndrome, steroidogenesisAutores:Geller D.H., Lee T.C., Richard J. Auchus, Worthy K.Fuentes:scopusThe regulation of 17,20 lyase activity
Conference ObjectAbstract: P450c17 is a single microsomal enzyme that catalyzes two distinct steroid biosynthetic activities: 1Palabras claves:17α-hydroxylase, adrenarche, molecular modeling, P450c17, serine phosphorylation, sex steroidAutores:Geller D.H., Miller W.L., Richard J. AuchusFuentes:scopus