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Endocrine Research(2)
Journal of Clinical Endocrinology and Metabolism(2)
Journal of Pediatric Endocrinology and Metabolism(1)
Molecular Endocrinology(1)
Nature Genetics(1)
Enzymatic activities of P450c17 stably expressed in fibroblasts from patients with the polycystic ovary syndrome
ArticleAbstract: Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting approximately 5-10% of womPalabras claves:Autores:Arlt W., Dunaif A., Geller D.H., Martens J.W.M., Miller W.L., Ossovskaya V.S., Richard J. Auchus, Rodriguez H.Fuentes:scopusP450c17 mutations R347H and R358Q selectively disrupt 17,20-lyase activity by disrupting interactions with P450 oxidoreductase and cytochrome b<inf>5</inf>
ArticleAbstract: Cytochrome P450c17 catalyzes steroid 17α-hydroxylase and 17,20-lyase activities and hence is a key ePalabras claves:Autores:Geller D.H., Miller W.L., Richard J. AuchusFuentes:scopusPitfalls in characterizing P450c17 mutations associated with isolated 17,20-lyase deficiency
ArticleAbstract: The cytochrome P450c17 enzyme system performs both the 17α-hydroxylase and 17,20-lyase reactions inPalabras claves:Autores:Geller D.H., Gupta M.K., Richard J. AuchusFuentes:scopusProbing structural and functional domains of human P450c17
Conference ObjectAbstract: Human P450c17 performs at least six chemical transformations, but this spectrum of activity is diffePalabras claves:Autores:Geller D.H., Miller W.L., Richard J. Auchus, Worthy K.Fuentes:scopusThe function and roles of P450c17 in androgen excess states
Conference ObjectAbstract: Cytochrome P450c17 is a multifunctional enzyme that converts C21 steroids to the C19 sex steroid prePalabras claves:17,20-Lyase, 17-Hydroxylase, 3β-Hydroxysteroid dehydrogenase/Δ(5/4)-isomerase, adrenarche, Dehydroepiandrosterone, P450c17, Polycystic ovary syndrome, steroidogenesisAutores:Geller D.H., Lee T.C., Richard J. Auchus, Worthy K.Fuentes:scopusThe genetic and functional basis of isolated 17, 20-lyase deficiency
OtherAbstract: Human male sexual differentiation requires production of fetal testicular testosterone, whose biosynPalabras claves:Autores:Geller D.H., Mendonça B.B., Miller W.L., Richard J. AuchusFuentes:scopusThe molecular basis of isolated 17,20 lyase deficiency
Conference ObjectAbstract: Human P450c17 catalyzes the 17α-hydroxylation of pregnenolone to 17OH pregnenolone and of progesteroPalabras claves:Autores:Geller D.H., Miller W.L., Richard J. AuchusFuentes:scopusThe regulation of 17,20 lyase activity
Conference ObjectAbstract: P450c17 is a single microsomal enzyme that catalyzes two distinct steroid biosynthetic activities: 1Palabras claves:17α-hydroxylase, adrenarche, molecular modeling, P450c17, serine phosphorylation, sex steroidAutores:Geller D.H., Miller W.L., Richard J. AuchusFuentes:scopusThe regulation of human P450c17 activity: Relationship to premature adrenarche, insulin resistance and the polycystic ovary syndrome
ArticleAbstract: The polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and insulin resistance, buPalabras claves:Autores:Geller D.H., Lee T.C., Miller W.L., Richard J. AuchusFuentes:scopus