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Low-dose versus standard-dose intravenous alteplase in acute ischemic stroke
ArticleAbstract: BACKGROUND: Thrombolytic therapy for acute ischemic stroke with a lower-than-standard dose of intravPalabras claves:Autores:Arima H., Bath P.M.W., Billot L., Broderick J.P., Cao Y., Chalmers J., Chen G., Chen X., Demchuk A.M., Donnan G.A., Huang Y., Kim J.S., Lavados P.M., Lee T.H., Levi C., Li Q., Lindley R.I., Martins S.O., Octavio Marques Pontes-Neto, Olavarria V.V., Pandian J.D., Parsons M.W., Ricci S., Robinson T.G., Roffe C., S Anderson C., Sharma V.K., Silva-Sieger F.A., Thang N.H., Wang J.G., Wang X., Woodward M.Fuentes:scopusIntensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial
ArticleAbstract: Background: Systolic blood pressure of more than 185 mm Hg is a contraindication to thrombolytic trePalabras claves:Autores:Arima H., Armenis M., Bai X., Baig M.A., Bath P.M.W., Benito D., Billot L., Blacklock N., Bousser M.G., Broderick J.P., Cao Y., Carcel C., Chalmers J., Chen G., Chen R., Chen X., Cong Y., Coutts S., Cui B., Delcourt C., Demchuk A.M., Deng H., Donnan G.A., Donnelly P., Durham A.C., Fuentes-Patarroyo S.X., Glass P., Gordon P., Guo Y., Hankey G.J., Haunton V., He R., Hirakawa Y., Huang Y., Ivanova E., Jenson K., Jia H., Kim J.S., Knight E., Kong L., Kumar N.N., Kunchok A., Lavados P.M., Levi C., Li Q., Lim J.Y., Lindley R.I., Liu L., Lv J., Malavera A., Manning L., Martins S.O., Minhas J.S., Mistri A., Monaghan H., Moullaali T.J., Naidu B., Octavio Marques Pontes-Neto, Odgers E., Olavarria V.V., Parsons M.W., Ricci S., Richtering S., Robinson T.G., S Anderson C., Sandercock P., Sanders E., Sato S., Scaria A., Sharma V.K., Silva-Sieger F.A., Simes R.J., Small S., Smith P., Song L., Stapf C., Tay N., Thang N.H., Thembani E., Tucker S., Vaghasiya R., Wang J.G., Wang X., Wardlaw J.M., Winters S., Wong K.S.L., Woodward M., Wu G., Xi Z., Yang J., Yoshimura S., You S., Zhang S., Zhao H., Zhu P.Fuentes:scopusRationale, design, and progress of the ENhanced Control of Hypertension ANd Thrombolysis strokE stuDy (ENCHANTED) trial: An international multicenter 2×2 quasi-factorial randomized controlled trial of low- vs. standard-dose rt-PA and early intensive vs. guideline-recommended blood pressure lowering in patients with acute ischaemic stroke eligible for thrombolysis treatment
ArticleAbstract: Rationale: Controversy exists over the optimal dose of intravenous (iv) recombinant tissue plasminogPalabras claves:Acute ischaemic stroke, Alteplase, Dose, Hypertension, Rt-PA, thrombolysisAutores:Arima H., Bath P.M.W., Broderick J.P., Chalmers J., Chen X., Demchuk A.M., Donnan G.A., Fuentes S., Huang Y., Kim J.S., Lavados P.M., Lee T.H., Levi C., Lindley R.I., Martins S.O., Nguyen T.H., Octavio Marques Pontes-Neto, Olavarria V.V., Pandian J.D., Parsons M.W., Ricci S., Robinson T.G., S Anderson C., Sharma V.K., Silva-Sieger F.A., Stapf C., Wang J.G., Woodward M.Fuentes:scopus