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B epitope multiplicity and B/T epitope orientation influence immunogenicity of foot-and-mouth disease peptide vaccines
ArticleAbstract: Synthetic peptides incorporating protective B- and T-cell epitopes are candidates for new safer footPalabras claves:Autores:Andreu D., B. G. De la Torre, Bárcena J., Blanco E., Cubillos C., Moreno N., Sobrino F.Fuentes:scopusBactericidal and membrane disruption activities of the eosinophil cationic protein are largely retained in an N-terminal fragment
ArticleAbstract: ECP (eosinophil cationic protein) is an eosinophil secretion protein with antipathogen activities inPalabras claves:Antimicrobial peptide, Electron microscopy, Host defence, LIPOPOLYSACCHARIDE, LiposomeAutores:Andreu D., B. G. De la Torre, Boix E., Nogués V., Torrent M.Fuentes:scopusAn optimized Fmoc synthesis of human defensin 5
Conference ObjectAbstract: Human α-defensin 5 (DEF5), expressed by the Paneth cells of human small intestine, plays an importanPalabras claves:ChemMatrix resin, Fmoc solid-phase peptide synthesis, Human defensin 5, Pseudoproline dipeptidesAutores:Andreu D., B. G. De la Torre, Valle J., Vernieri E.Fuentes:scopusA BODIPY-embedding miltefosine analog linked to cell-penetrating Tat(48-60) peptide favors intracellular delivery and visualization of the antiparasitic drug
ArticleAbstract: Therapeutic application of many drugs is often hampered by poor or denied access to intracellular taPalabras claves:BODIPY, cell-penetrating peptide, Dual fluorescent labeling, Miltefosine, Monitoring of intracellular drug delivery, Reversion of resistanceAutores:Abengózar M.Á., Amat-Guerri F., Andreu D., B. G. De la Torre, Hornillos V., Luque-Ortega J.R., Rivas L., Ulises Acuña A.Fuentes:scopusA T-cell epitope on NS3 non-structural protein enhances the B and T cell responses elicited by dendrimeric constructions against CSFV in domestic pigs
ArticleAbstract: It has been recently reported by our group that dendrimeric constructs combining B- and T-cell epitoPalabras claves:Cellular and humoural immune response, Classical swine fever virus, Dendrimeric peptide vaccine, Epitopes, Marker (DIVA) vaccineAutores:Andreu D., B. G. De la Torre, Domingo M., Fraile L., Ganges L., Monsó M., Muñoz M., Nofrarías M., Pérez L.J., Riquelme C., Rosell R., Sobrino F., Tarradas J.Fuentes:scopusA genetic fiber modification to achieve matrix-metalloprotease-activated infectivity of oncolytic adenovirus
ArticleAbstract: Selective tumor targeting of oncolytic adenovirus at the level of cell entry remains a major challenPalabras claves:Cancer-associated fibroblasts, Metalloproteases, oncolytic adenovirus, pancreatic cancer, Tumor targetingAutores:Alemany R., Andreu D., B. G. De la Torre, Fillat C., Giménez-Alejandre M., José A., Luna J., Rovira-Rigau M., Vaquero E.Fuentes:scopusEnhanced mucosal immunoglobulin A response and solid protection against foot-and-mouth disease virus challenge induced by a novel dendrimeric peptide
ArticleAbstract: The successful use of a dendrimeric peptide to protect pigs against challenge with foot-and-mouth diPalabras claves:Autores:Andreu D., B. G. De la Torre, Bárcena J., Blanco E., Borrás E., Clementi G., Cubillos C., Jakab A., Sobrino F.Fuentes:scopusEssential Role of Enzymatic Activity in the Leishmanicidal Mechanism of the Eosinophil Cationic Protein (RNase 3)
ArticleAbstract: The recruitment of eosinophils into Leishmania lesions is frequently associated with a favorable evoPalabras claves:Antimicrobial peptide, cell-penetrating enzyme, membrane disruption, protozoa, RNaseAutores:Abengózar M.Á., Andreu D., B. G. De la Torre, Boix E., Fernández-Reyes M., Rivas L., Salazar V.A., Torrent M.Fuentes:scopusEfficacy of cecropin A-melittin peptides on a sepsis model of infection by pan-resistant Acinetobacter baumannii
ArticleAbstract: Pan-resistant Acinetobacter baumannii have prompted the search for therapeutic alternatives. We evalPalabras claves:Autores:Andreu D., B. G. De la Torre, Bengoechea J.A., Docobo-Pérez F., Fernández-Reyes M., López-Rojas R., March C., Pachón J., Pachón-Ibañez M.E., Rivas L.Fuentes:scopusMonitoring antibacterial permeabilization in real time using time-resolved flow cytometry
ArticleAbstract: Despite the intensive study of antibiotic-induced bacterial permeabilization, its kinetics and molecPalabras claves:Antimicrobial action, Antimicrobial peptide, LIPOPOLYSACCHARIDE, Live/dead assay, Peptidelipid interaction, time-resolved flow cytometryAutores:Andreu D., B. G. De la Torre, Castanho M.A.R.B., Freire J.M., Gaspar D., Veiga A.S.a.Fuentes:scopus