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Challenges and Opportunities for Clinical Pharmacogenetic Research Studies in Resource-limited Settings: Conclusions From the Council for International Organizations of Medical Sciences–Ibero-American Network of Pharmacogenetics and Pharmacogenomics Meeting
ArticleAbstract: Purpose: The symposium Health and Medicines in Indigenous Populations of America was organized by thPalabras claves:CIOMS-RIBEF, clinical research, pharmacogenetics, resource-limited settingsAutores:Adrián LLerena, Diwakar S., Enrique Terán, Galaviz-Hernandez C., Gil J.P., Isabel Hernández, Lara-Riegos J., Molina-Guarneros J.A., Moya G.E., Nair S., Penãs-Lledó E.M., Rägo L., Ramírez-Roa R., Sosa-Macías M.G., Tarazona-Santos E.M., Verde I.Fuentes:googlescopusFrequency of CYP2C9 (*2, *3 and IVS8-109A>T) allelic variants, and their clinical implications, among mexican patients with diabetes mellitus type 2 undergoing treatment with glibenclamide and metformin
ArticleAbstract: The majority of Mexican patients with diabetes mellitus type 2 (DMT2) (67.9-85.0%) are prescribed suPalabras claves:Cytochrome P450 2C9, DIABÉTES, Glibenclamide, Glycated hemoglobin A1c, MetforminAutores:Adrián LLerena, Castillo-Nájera F., Cuautle-Rodríguez P., de Andrés F., Molina-Guarneros J.A., Rodríguez-Rivera N.S.Fuentes:scopusPharmacogenetics of Metformin Transporters Suggests No Association with Therapeutic Inefficacy among Diabetes Type 2 Mexican Patients
ArticleAbstract: Mexico has been under official epidemiological alert due to diabetes since 2016. This study presentsPalabras claves:Diabetes type 2, Metformin, pharmacogenetics, sulphonylureas, therapeutic inefficacy, TransportersAutores:Adrián LLerena, de Andrés F., Espinosa-Sánchez A.G., Molina-Guarneros J.A., Ortega-Ayala A., Pérez-Silva E., Rodríguez-Rivera N.S.Fuentes:scopusPresent status and perspective of pharmacogenetics in Mexico
ReviewAbstract: Drug costs account for up to 24% of the country's health expenditure and there are 13,000 registeredPalabras claves:Cytochrome p450, Drug-metabolizing enzymes, Interindividual variability, pharmacogenetics, Phenotyping cocktailsAutores:Adrián LLerena, Cuautle-Rodríguez P., Molina-Guarneros J.A.Fuentes:scopus