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scopus(4)
G-protein-coupled receptors oligomerization: Emerging signaling units and new opportunities for drug design
ArticleAbstract: G-protein-coupled receptors (GPCRs) are a widespread family of transmembrane receptors with differenPalabras claves:Dimers, disease, drug design, G-protein-coupled receptors, ligand, OligomerizationAutores:Borroto-Escuela D.O., Fuxe K., Garriga P., Ramon E., Rivera D., Tena-Campos M., W. Romero-FernandezFuentes:scopusDissecting the conserved NPxxY motif of the M <inf>3</inf> muscarinic acetylcholine receptor: Critical role of Asp-7.49 for receptor signaling and multiprotein complex formation
ArticleAbstract: Acetylcholine challenge produces M 3 muscarinic acetylcholine receptor activation and accessory/scafPalabras claves:Desensitization, G protein-coupled receptors, Monomeric small G proteins, Muscarinic acetylcholine receptors, NPxxY motif, Phospholipase C, Phospholipase DAutores:Borroto-Escuela D.O., Ciruela F., Correia P.A., Fuxe K., García-Negredo G., Garriga P., W. Romero-FernandezFuentes:scopusDiversity and bias through receptor-receptor interactions in GPCR heteroreceptor complexes. Focus on examples from dopamine D2 receptor heteromerization
ReviewAbstract: Allosteric receptor-receptor interactions in GPCR heteromers appeared to introduce an intermolecularPalabras claves:allosteric modulation, Biased recognition, Biased signaling, G protein-coupled receptor, Heterodimerization, Receptor diversity, Receptor heterodimers, Receptor-receptor interactionsAutores:Agnati L.F., Borroto-Escuela D.O., Díaz-Cabiale Z., Ferraro L., Filip M., Fuxe K., Garriga P., Tanganelli S., Tarakanov A.O., W. Romero-FernandezFuentes:scopusOverproduction of human M<inf>3</inf> muscarinic acetylcholine receptor: An approach toward structural studies
ArticleAbstract: Human M3 muscarinic acetylcholine receptor (M3R), present in both the central and the peripheral nerPalabras claves:Codon optimization, Epitope tags, G-protein-coupled receptors, Muscarinic receptor, Overexpression, Semliki forest virusAutores:Borroto-Escuela D.O., Garriga P., W. Romero-FernandezFuentes:scopus