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Development of a novel virtual screening cascade protocol to identify potential trypanothione reductase inhibitors
ArticleAbstract: The implementation of a novel sequential computational approach that can be used effectively for virPalabras claves:Autores:Andrew L.C., Burgos A., Fairlamb A.H., Hortensia Rodriguez Cabrera, Jones D.C., Perez-Pineiro R., Suárez Navarro M., Wishart D.S.Fuentes:googlescopusGlutathionylspermidine metabolism in Escherichia coli
ArticleAbstract: Intracellular levels of glutathione and glutathionylspermidine conjugates have been measured throughPalabras claves:Autores:Adolfo Borges, Ariyanayagam M.R., Fairlamb A.H., Smith K.Fuentes:scopusTrypanosoma cruzi trypanothione reductase: Crystallization, unit cell dimensions and structure solution
ArticleAbstract: We have reproducibly crystallized recombinant trypanothione reductase from Trypanosoma cruzi. YellowPalabras claves:Molecular replacement, Protein crystallization, Trypanothione reductase, X-Ray diffractionAutores:Adolfo Borges, Bailey S., Bond C., Cunningham M.L., Fairlamb A.H., Habash J., Hunter W., McLaughlin P., Naismith J.H., Papiz M., Zhang Y.Fuentes:scopusRationally designed selective inhibitors of trypanothione reductase: Phenothiazines and related tricyclics as lead structures
ArticleAbstract: Trypanothione reductase, an essential component of the anti-oxidant defences of parasitic trypanosomPalabras claves:Autores:Adolfo Borges, Benson T., Douglas K., Fairlamb A.H., Garforth J., McKie J.Fuentes:scopusSite‐Directed Mutagenesis of the Redox‐Active Cysteines of Trypanosoma cruzi Trypanothione Reductase
ArticleAbstract: The gene for trypanothione reductase from the Silvio strain of Trypanosoma cruzi has been cloned, sePalabras claves:expression, flavoprotein disulphide oxido‐reductase, reaction mechanism, Trypanothione reductaseAutores:Adolfo Borges, Cunningham M.L., Fairlamb A.H., Tovar J.Fuentes:scopus