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Association among Terminally Differentiated T Cells, Frailty, and Dependency in a Group of Cuban Centenarians
ArticleAbstract: Introduction: Centenarians are considered a model of successful aging. Cuba exhibits one of the oldePalabras claves:Centenarians, Frailty, Immunosenescence, inflammation, terminally differentiated T cellsAutores:Añe-Kouri A.L., Bicet Y.D.L.C., González A., Lage Davila A., Ledón N., Llanez-Gregorich E., Luaces P.L.o., Pereira K., Ramos M.B., Rodríguez M., Rodríguez Y., Saavedra Hernández D., Silva A., Suárez G.M., Tania Crombet, Vidal A.Fuentes:scopusAssociations among cytokines, EGF and lymphocyte subpopulations in patients diagnosed with advanced lung cancer
ArticleAbstract: Aging is considered the single most significant risk factor for the majority of common malignances iPalabras claves:B cells, Epidermal growth factor, Pro-inflammatory cytokines, T cells, terminally differentiated T cellsAutores:Añe-Kouri A.L., Catala M., Cordero L., García Verdecia B., González A., Lage Davila A., Ledón N., Luaces P.L.o., Mazorra Z., Neninger Vinageras E., Pereira K., Saavedra Hernández D., Salomón E.E., Sánchez M.G., Suárez G.M., Tania CrombetFuentes:scopusAugmenting antibody response to EGF-depleting immunotherapy: Findings from a phase I trial of CIMAvax-EGF in combination with nivolumab in advanced stage NSCLC
ArticleAbstract: Background: CIMAvax-EGF is an epidermal growth factor (EGF)-depleting immunotherapy which has shownPalabras claves:immune checkpoint inhibitor, immunotherapy, lung cancer, Non-small cell lung cancer, VaccineAutores:Attwood K., Cedeno C., Cinquino A., Dai T., Dozier A., Dy G.K., Ernstoff M., Evans R., Fisher D.T., Fountzilas C., Groman A., Hutson A., Johnson C., Lage Davila A., Lee K., Leon K., Luaces P.L.o., Mazorra Z., Mesa C., Muhitch J., Opyrchal M., Puzanov I., Reid M., Saavedra Hernández D., Santos-Morales O., Tania Crombet, Wallace P.K.Fuentes:scopusBiomarkers related to immunosenescence: relationships with therapy and survival in lung cancer patients
ArticleAbstract: Purpose: There are well-known alterations occurring within the immune system with aging. CollectivelPalabras claves:cancer vaccine, Immunosenescence, Immunosenescence markers, Non-small cell lung cancerAutores:Fuentes K.P., García Verdecia B., González A., Lage Davila A., Luaces P.L.o., Mazorra Z., Neninger Vinageras E., Popa X., Saavedra Hernández D., Tania CrombetFuentes:scopusBiomodulina T partially restores immunosenescent CD4 and CD8 T cell compartments in the elderly
ArticleAbstract: The changes that occur in the immune system with aging are commonly termed immunosenescence. ImmunosPalabras claves:Biomodulina T, Immunosenescence, naïve T cells, Stem cell-like memory T cells, T cellsAutores:Aznar E., Fuertes S.A., García Verdecia B., González A., Lage Davila A., Luaces P.L.o., Mazorra Z., Saavedra Hernández D., Speiser D.E., Suárez G.M., Tania CrombetFuentes:scopusImmunosenescence and gender: A study in healthy Cubans
ArticleAbstract: Background: The progressive decline in the immune function during ageing is termed immunosenescence.Palabras claves:Autores:de Jesús Badía Alvarez T., García Verdecia B., Lage Davila A., Leonard Rupalé I., Luaces P.L.o., Mazorra Z., Saavedra Hernández D., Tania CrombetFuentes:scopusShort communication: Phase I clinical evaluation of a neutralizing monoclonal antibody against epidermal growth factor receptor in advanced brain tumor patients: Preliminary study
ArticleAbstract: High levels of growth factors and their receptors have been demonstrated in human tumors. Gliomas anPalabras claves:Autores:Figueredo R., Iznaga N., Lage Davila A., Menéndez A., Pérez R., Ramos M., Rodríguez V., Stevenson A., Tania Crombet, Torres F., Torres O., Veitía I.Fuentes:scopusThymic Polypeptide Fraction Biomodulina T Decreases Exhausted and Terminally Differentiated EMRA T Cells in Advanced Lung Cancer Patients Treated With Platinum-Based Chemotherapy
ArticleAbstract: Lung cancer is the second cause of cancer related deaths worldwide. Chemotherapy and immunotherapy rPalabras claves:Biomodulina T, CIMAvax-EGF, naïve T cells, Non-small-cell lung cancer, PD-1, terminally differentiated T cellsAutores:Añe-Kouri A.L., Catala M., Díaz M., González A., Hernández J.d.l.C., Lage Davila A., Ledón N., Luaces P.L.o., Mazorra Z., Molina M.d.l.A., Peña Y., Pereira K., Portela S., Ramos R., Reyes M.C., Saavedra Hernández D., Suárez G.M., Tania CrombetFuentes:scopus