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Cleaving protected peptides from 2-chlorotrityl chloride resin. Moving away from dichloromethane
ArticleAbstract: In recent years, the work of various research groups has allowed the substitution of the hazardous sPalabras claves:Autores:Al Musaimi O., Alberício F., Alhassan M., B. G. De la Torre, Collins J.M.Fuentes:scopusBypassing osmotic shock dilemma in a polystyrene resin using the green solvent cyclopentyl methyl ether (CPME): A morphological perspective
ArticleAbstract: The "osmotic shock" phenomenon is the main thing that is responsible for morphological structure altPalabras claves:Green solvent, Osmotic shock, Solid-phase peptide synthesisAutores:Al Musaimi O., Alberício F., Almarhoon Z.M., B. G. De la Torre, Basso A., El-Faham A.Fuentes:scopusAnalytical methodologies to assure successful peptide synthesis when utilizing polystyrene/DVB resins
ArticleAbstract: Solid-phase peptide synthesis has become an important technique as the method of choice to deliver hPalabras claves:Fluorenylmethoxycarbonyl (Fmoc), Functionalization, MORPHOLOGY, Peer Reviewed, Polystyrene resins, Solid support, Solid-phase peptide synthesis, swellingAutores:Al Musaimi O., Alberício F., Alhassan M., B. G. De la Torre, Basso A., Serban S., Summers B.D.Fuentes:scopus2017 FDA peptide harvest
ReviewAbstract: 2017 was an excellent year in terms of new drugs (chemical entities and biologics) approved by the FPalabras claves:Drug Discovery, drugs, Pharmaceutical market, Solid-phase peptide synthesisAutores:Al Musaimi O., Al Shaer D.M., Alberício F., B. G. De la TorreFuentes:scopus2018 FDA Tides Harvest
ReviewAbstract: In 2018, the United States Food and Drug Administration (FDA) approved a total of 59 new drugs, threPalabras claves:Dotatate, drugs, Inotersen, Lutathera, Oligonucleotides, Onpattro, Patisiran, Peptides, Pharmaceutical market, TegsediAutores:Al Musaimi O., Al Shaer D.M., Alberício F., B. G. De la TorreFuentes:scopus2022 FDA TIDES (Peptides and Oligonucleotides) Harvest
ArticleAbstract: A total of 37 new drug entities were approved in 2022; although that year registered the lowest numbPalabras claves:drugs, FDA, gadopiclenol, lutetium ( Lu) vipivotide tetraxetan 177, Oligonucleotides, Peptides, terlipressin, tirzepatide, vutrisiranAutores:Al Musaimi O., Al Shaer D.M., Alberício F., B. G. De la TorreFuentes:scopusCalculating Resin Functionalization in Solid-Phase Peptide Synthesis Using a Standardized Method based on Fmoc Determination
ArticleAbstract: Solid-phase synthesis is the method of choice for peptide preparation in both research and industriaPalabras claves:Fmoc, resin functionalization, solid-phase synthesis, standardizationAutores:Al Musaimi O., Alberício F., B. G. De la Torre, Basso A.Fuentes:scopusGreening Fmoc/: T Bu solid-phase peptide synthesis
ReviewAbstract: Peptides are gaining considerable attention as potential drugs. The so-called Fmoc/tBu solid-phase sPalabras claves:Autores:Al Musaimi O., Alberício F., B. G. De la TorreFuentes:scopusGreening the Solid-Phase Peptide Synthesis Process. 2-MeTHF for the Incorporation of the First Amino Acid and Precipitation of Peptides after Global Deprotection
ArticleAbstract: In solid-phase peptide synthesis, dichloromethane is the predominant solvent used to incorporate thePalabras claves:2-MeTHF, Dipeptide formation, incorporation, precipitation, Racemization, Solid-phase peptide synthesisAutores:Al Musaimi O., Alberício F., B. G. De la Torre, Basso A., Collins J.M., El-Faham A., Jad Y.E., Kumar A.Fuentes:scopusHydroxamate siderophores: Natural occurrence, chemical synthesis, iron binding affinity and use as Trojan horses against pathogens
ReviewAbstract: Hydroxamic acids are an important class of molecules, in particular because of their metal-chelatingPalabras claves:Fe (III) binding affinity, Hydroxamate, Sideromycins, Siderophore, Siderophore-drug conjugate, Trojan horseAutores:Al Musaimi O., Al Shaer D.M., Alberício F., B. G. De la TorreFuentes:scopus