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Bovine milk-derived exosomes as a drug delivery vehicle for mirna-based therapy
ArticleAbstract: MicroRNAs (miRNAs) are small non-coding RNAs with a known role as mediators of gene expression in crPalabras claves:Bovine milk, exosomes, Extracellular vesicles, miRNAs, Size exclusion chromatographyAutores:Almudena García-Ruiz, Busto R., Dávalos A., del Pozo-Acebo L., Gil-Cabrerizo P., López de Las Hazas M.C., San-Cristobal R., Tomé-Carneiro J.Fuentes:scopusDietary bovine milk miRNAs transported in extracellular vesicles are partially stable during GI digestion, are bioavailable and reach target tissues but need a minimum dose to impact on gene expression
ArticleAbstract: PURPOSE: Extracellular RNAs are unstable and rapidly degraded unless protected. Bovine-milk extracelPalabras claves:exosomes, Extracellular vesicles, in vitro digestion, Milk miRNAs, Transcriptome, TransfectionAutores:Almudena García-Ruiz, Dávalos A., del Pozo-Acebo L., Gil-Zamorano J., Gómez-Coronado D., Hansen M.S., López de Las Hazas M.C., Mantilla-Escalante D.C., Marín F., Rasmussen J.T.Fuentes:scopusEating microRNAs: pharmacological opportunities for cross-kingdom regulation and implications in host gene and gut microbiota modulation
ReviewAbstract: Cross-kingdom communication via non-coding RNAs is a recent discovery. Exogenous microRNAs (exog-miRPalabras claves:cross species, cross-kingdom, diet, Digestion, exosomes, food safety, miRNAs, ncRNAAutores:Almudena García-Ruiz, Dávalos A., del Pozo-Acebo L., López de Las Hazas M.C., Margollés A.Fuentes:scopusOne-year dietary supplementation with walnuts modifies exosomal miRNA in elderly subjects
ArticleAbstract: Purpose: Epidemiological studies and clinical trials support the association of nut consumption withPalabras claves:c-miRNA, Dietary intervention, exosomes, lipidomics, WalnutsAutores:Almudena García-Ruiz, Cofán M., Dávalos A., del Pozo-Acebo L., Doménech M., Gil-Zamorano J., López de Las Hazas M.C., Mantilla-Escalante D.C., Mazzeo C., Pastor O., Rajaram S., Ros E., Sabate J., Sala-Vila A., Serra-Mir M., Valls-Pedret C., Yáñez-Mó M.Fuentes:scopusInterplay of Walnut Consumption, Changes in Circulating miRNAs and Reduction in LDL-Cholesterol in Elders
ArticleAbstract: The mechanisms underlying the lipid-lowering effect of nuts remain elusive. This study explores whetPalabras claves:alpha-linolenic acid, Biomarkers, cholesterol, lipid metabolism, nutsAutores:Almudena García-Ruiz, Cofán M., Dávalos A., Doménech M., García-Blanco T., Gil-Zamorano J., López de Las Hazas M.C., Rajaram S., Ros E., Roth I., Sabate J., Sala-Vila A., Serra-Mir M., Valls-Pedret C.Fuentes:scopusPreparation of antioxidant enzymatic hydrolysates from α-lactalbumin and β-lactoglobulln. Identification of active peptides by HPLC-MS/MS
ArticleAbstract: We have investigated the antioxidant activity of hydrolysates from whey proteins bovine α-lactalbumiPalabras claves:Mass spectrometry, Peptides, Radical scavenging activity, α-Lactalbumin, β-lactoglobullnAutores:Bartolome B., Dávalos A., Hernandez-Ledesma B., Lourdes AmigoFuentes:scopusPostprandial circulating miRNAs in response to a dietary fat challenge
ArticleAbstract: Postprandial lipemia has many physiopathological ekects, some of which increase the risk of cardiovaPalabras claves:Circulating miRNA, diet, exosomes, Fat challenge, PostprandialAutores:Almudena García-Ruiz, Briand O., Cardona F., Cornejo-Pareja I., Crespo M.C., Dávalos A., del Pozo-Acebo L., del Saz A., Gil-Zamorano J., Lasunción M.A., López de Las Hazas M.C., Mantilla-Escalante D.C., Martín-Hernández R., Tomé-Carneiro J., Visioli F.Fuentes:scopus