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Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling
ArticleAbstract: The Ebola virus (EBOV) VP35 protein blocks the virus-induced phosphorylation and activation of interPalabras claves:Autores:Basler C.F., Gale M., Hartman A., Kimberlin C., Loo Y.M., Martínez-Sobrido L., Saphire E., Washington B. CárdenasFuentes:googlescopusEbola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKε and TBK-1
ArticleAbstract: The Ebola virus (EBOV) VP35 protein antagonizes the early antiviral alpha/beta interferon (IFN-α/β)Palabras claves:Autores:Basler C.F., Prins K.C., Washington B. CárdenasFuentes:googlescopusMutations abrogating VP35 interaction with double-stranded RNA render Ebola virus avirulent in guinea pigs
ArticleAbstract: Ebola virus (EBOV) protein VP35 is a double-stranded RNA (dsRNA) binding inhibitor of host interferoPalabras claves:Autores:Amarasinghe G.K., Basler C.F., Delpeut S., Leung D.W., Prins K.C., Ramanan P., Reid S.P., Reynard O., Volchkov V.E., Volchkova V.A., Washington B. CárdenasFuentes:googlescopusNuclear localization of the Nipah virus W protein allows for inhibition of both virus- and Toll-like receptor 3-triggered signaling pathways
ArticleAbstract: The Nipah virus V and W proteins, which are encoded by the P gene via RNA editing, have a common N-tPalabras claves:Autores:Basler C.F., Palese P., Shaw M., Washington B. Cárdenas, Zamarin D.Fuentes:googlescopusHomo-oligomerization facilitates the interferon-antagonist activity of the ebolavirus VP35 protein
ArticleAbstract: We have identified a putative coiled-coil motif within the amino-terminal half of the ebolavirus VP3Palabras claves:Ebolavirus VP35 protein, Homo-oligomerization, INTERFERÓNAutores:Basler C.F., Reid S.P., Washington B. CárdenasFuentes:googlescopusThe tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response
ArticleAbstract: On detecting viral RNAs, the RNA helicase retinoic acid-inducible gene I (RIG-I) activates the interPalabras claves:Autores:Basler C.F., Friedman C., Horvath C., Komuro A., Legarda-Addison D., Moran T., Ng A., O'Donnell M., Ting A., Washington B. Cárdenas, Xavier R., Yount J.Fuentes:googlescopus