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A strong protective action of Guttiferone-A, a naturally occurring prenylated benzophenone, against iron-induced neuronal cell damage
ArticleAbstract: Guttiferone-A (GA) is a natural occurring polyisoprenylated benzophenone with several reported pharmPalabras claves:antioxidant, Guttiferone-A, Iron, Iron chelation, neuroprotectionAutores:Curti C., García-Pupo L., Naal Z., Núñez-Figueredo Y., Osmany Cuesta-Rubio, Pardo-Andreu G.L., René D.H.Fuentes:googlescopusEffect of a new series of synthetic spiroteroids on the PC12 cell line viability
ArticleAbstract: Introduction: diosgenin and its derivatives have been described as potent anti-proliferative compounPalabras claves:Cytotoxicity, Spirosteroids, Structure-activity relationship, Taurodeoxycholic acidAutores:García-Pupo L., Juan Enrique Tacoronte-Morales, Núñez-Figueredo Y., René D.H.Fuentes:scopusNeuroprotective action and free radical scavenging activity of guttiferone-A, a naturally occurring prenylated benzophenone
ArticleAbstract: Reactive oxygen species (ROS) are important mediators in a number of neurodegenerative diseases andPalabras claves:glutamate, Guttiferone-A, Hydrogen Peroxide, neuroprotective drug, PC12 cells, rat cortical neuronsAutores:Alcántara-Isaac Y., Curti C., García-Pupo L., Hernández R.D., Naal Z., Núñez-Figueredo Y., Osmany Cuesta-Rubio, Pardo-Andreu G.L., Ramírez-Sánchez J.Fuentes:googlescopusIn vitro neuroprotective and anti-inflammatory activities of natural and semi-synthetic spirosteroid analogues
ArticleAbstract: Two spirosteroid analogues were synthesized and evaluated for their in vitro neuroprotective activitPalabras claves:Excitotoxicity, inflammatory mediators, neuroprotection, SpirosteroidsAutores:Exarchou V., García-Pupo L., Juan Enrique Tacoronte-Morales, Núñez-Figueredo Y., Pieters L., René D.H., Vanden Berghe W., Zaldo-Castro A.Fuentes:scopus