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Assessing the (a)symmetry of concentration-effect curves: Empirical versus mechanistic models
ReviewAbstract: Modeling the shape of concentration-effect curves is of prime importance in pharmacology. GeometricPalabras claves:asymmetry, Curve fitting, G-protein-coupled receptors, Ionic channels, Receptor reserve, Slope parameterAutores:Badia A., Elisabet Vila, Giraldo J., Vivas N.M.Fuentes:scopusAdrenergic and purinergic components in bisected vas deferens from spontaneously hypertensive rats
ArticleAbstract: 1. Purinergic and adrenergic components of the contractile response to electrical field stimulationPalabras claves:Epididymal half, Noradrenergic neurotransmission, Prostatic half, Purinergic neurotransmission, SHR, Vas deferensAutores:Badia A., Elisabet Vila, Giraldo J., Goñalons E., Guitart M.Fuentes:scopusAgeing affects nitric oxide synthase, cyclooxygenase and oxidative stress enzymes expression differently in mesenteric resistance arteries
ArticleAbstract: Our aim was to study the role of nitric oxide (NO) and arachidonic acid pathways in the α1-adrenocepPalabras claves:ageing, Cyclooxygenase, nitric oxide synthase, Oxidative Stress, Resistance arteriesAutores:Briones A.M., Elisabet Vila, Giraldo J., Montoya N.Fuentes:scopusEndothelial modulation of α<inf>1</inf>-adrenoceptor contractile responses in the tail artery of spontaneously hypertensive rats
ArticleAbstract: 1. Vascular contraction induced by phenylephrine was studied in tail artery rings from spontaneouslyPalabras claves:endothelium, Hypertension, Tail artery, [ H]-prazosin binding 3, α -Adrenoceptors 1Autores:Badia A., Elisabet Vila, Giraldo J., Tabernero A., Vivas N.M.Fuentes:scopusEnhanced noradrenergic transmission in the spontaneously hypertensive rat anococcygeus muscle
ArticleAbstract: 1. There is a long-known hyper-responsiveness of vascular adrenergic transmission in the spontaneousPalabras claves:Adrenergic innervation, Anococcygeus muscle, Nonadrenergic, Noncholinergic innervation, SHRAutores:Elisabet Vila, Giraldo J., Jiménez-Altayó F., McGrath J.C.Fuentes:scopusEffect of N<sup>G</sup>-nitro-L-arginine methylester (L-NAME) on functional and biochemical α<inf>1</inf>-adrenoceptor-mediated responses in rat blood vessels
ArticleAbstract: 1. The modulation by NG-nitro-L-arginine methylester (L-NAME) of α1-adrenoceptor-mediated contractioPalabras claves:N -nitro-L-arginine methylester G, Phophoinositide hydrolysis, Rat aorta, St-587, Tail artery, α -Adrenoceptors 1Autores:Elisabet Vila, Giraldo J., Tabernero A.Fuentes:scopusEffects of L-N(G)-nitro-arginine on noradrenaline induced contraction in the rat anococcygeus muscle
ArticleAbstract: 1. The influence of L-N(G)-nitro-arginine (L-NOARG, 30 μM) on contractile responses to exogenous norPalabras claves:Anococcygeus muscle (rat), L-N(G)-nitro-arginine, NANC transmission, α -adrenoceptor 1Autores:Elisabet Vila, Giraldo J., Hoyo Y.Fuentes:scopusIncreased superoxide anion production by interleukin-1β impairs nitric oxide-mediated relaxation in resistance arteries
ArticleAbstract: The present study was designed to analyze the effect of long-term incubation with interleukin-1β (ILPalabras claves:Autores:Briones A.M., Elisabet Vila, Giraldo J., Jiménez-Altayó F., Planas A.M., Salaices M.Fuentes:scopusModelling the changes due to the endothelium and hypertension in the α-adenoreceptor-mediated responses of rat aorta
ArticleAbstract: 1. The present study focuses on the role of endothelium on α1-adrenoceptor-mediated vasoconstrictionPalabras claves:Autores:Elisabet Vila, Giraldo J., Tabernero A.Fuentes:scopusModelling the changes induced by chronic desipramine treatment on the factors governing the agonism at prejunctional α<inf>2</inf>-adrenoceptors
ArticleAbstract: 1. The adaptational changes induced after chronic desipramine treatment on functional responsivenessPalabras claves:Agonist affinities, Agonist efficacies, Clonidine, Desensitization, Desipramine, Operational model, Prejunctional α -adrenoceptors 2, Rat vas deferens, XylazineAutores:Badia A., Elisabet Vila, Giraldo J., Sallés J.Fuentes:scopus