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Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairment
ArticleAbstract: The polymorphic CYP2C19 enzyme metabolizes psychoactive compounds and is expressed in the adult livePalabras claves:Autores:Adrián LLerena, Baune B.T., Binder E.B., Carrillo-Roa T., Courtet P., Dannlowski U., de Quervain D.J., Ingelman-Sundberg M., Jukić M.M., Miksys S., Novalen M., Opel N., Papassotiropoulos A., Penãs-Lledó E.M., Renblom A., Sim S.C., Ström J., Tyndale R.F.Fuentes:scopusErratum: Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairment (Molecular Psychiatry, (2017), 22, 8, (1155-1163), 10.1038/mp.2016.204)
OtherAbstract: Correction to: Molecular Psychiatry advance online publication, 29 November 2016; doi: 10.1038/mp.20Palabras claves:Autores:Adrián LLerena, Baune B.T., Binder E.B., Carrillo-Roa T., Courtet P., Dannlowski U., de Quervain D.J., Ingelman-Sundberg M., Jukić M.M., Miksys S., Novalen M., Opel N., Papassotiropoulos A., Penãs-Lledó E.M., Renblom A., Sim S.C., Ström J., Tyndale R.F.Fuentes:scopusHigh frequency and founder effect of the CYP3A4∗20 loss-of-function allele in the Spanish population classifies CYP3A4 as a polymorphic enzyme
ArticleAbstract: Cytochrome P450 3A4 (CYP3A4) is a key drug-metabolizing enzyme. Loss-of-function variants have beenPalabras claves:Autores:Adrián LLerena, Apellániz-Ruiz M., Carracedo Á., Cascón A., Comino-Méndez I., Currás-Freixes M., De Cubas A.A., Grazina M., Ingelman-Sundberg M., Inglada-Pérez L., Mancikova V., Moya G.E., Naranjo M.E.G., Opocher G., Rasool M., Rebai A., Robledo M., Rodríguez-Antona C., Sánchez L., Taboada-Echalar P., Triki S.Fuentes:scopusPharmacogenomic information in drug labels: European Medicines Agency perspective
ReviewAbstract: Pharmacogenomics (PGx) has a growing impact on healthcare and constitutes one of the major pillars oPalabras claves:Autores:Adrián LLerena, Caneva L., Ehmann F., Ingelman-Sundberg M., Maliepaard M., Papaluca-Amati M., Paulmichl M., Prasad K.Fuentes:scopus