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Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation
ArticleAbstract: Pyrin responds to pathogen signals and loss of cellular homeostasis by forming an inflammasome complPalabras claves:Autores:Amselem S., Baker P.J., Cochet E., Copin B., Dagley L.F., De Nardo D., De Somer L., Dooley J., Goris A., Holley C.L., Jeandel P.Y., Jéru I., Josselyn E. Garcia-Perez, Lagou V., Lawless D., Liston A., Lyras D., Masters S.L., Medlej-Hashim M., Megarbane A., Moghaddas F., Nicholson S.E., Parry D.A., Pasciuto E., Ruuth-Praz J., Savic S., Schroder K., Sciot R., Van Eyck L., Van Nieuwenhove E., Webb A.I., Wouters C.H.Fuentes:scopusGenetic Architecture of Adaptive Immune System Identifies Key Immune Regulators
ArticleAbstract: The immune system is highly diverse, but characterization of its genetic architecture has lagged behPalabras claves:adaptive immune system, association, autoimmunity, Genetics, Genome-wide association, immune phenotype, susceptibilityAutores:Boeckxstaens G., Bowness P., Chen L., Dooley J., Dubois B., Goris A., Hilven K., Humblet-Baron S., Josselyn E. Garcia-Perez, Lagou V., Liston A., Mallants K., Moisse M., Prezzemolo T., Smets I., Van Damme P., Van Horebeek L., Vandebergh M.Fuentes:scopusGenetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes
ArticleAbstract: Type 1 (T1D) and type 2 (T2D) diabetes share pathophysiological characteristics, yet mechanistic linPalabras claves:Autores:Allemeersch J., Carr E.J., Chabot-Roy G., Dahlstrom J.E., Delghingaro-Augusto V., Di Marino D., Dooley J., Franckaert D., Gevaert K., Goodnow C.C., Jetten A.M., Josselyn E. Garcia-Perez, Lagou V., Lambrechts D., Laybutt D.R., Lesage S., Linterman M.A., Liston A., Lyssenko V., Nolan C.J., Oskolkov N., Overbergh L., Pasciuto E., Petrovsky N., Schlenner S.M., Schönefeldt S., Socha L., Tian L., Vandenbussche J.Fuentes:scopusA kindred with mutant IKAROS and autoimmunity
ArticleAbstract:Palabras claves:Autores:Claessens F., Dooley J., Frietze S., Gijsbers R., Helsen C., Humblet-Baron S., Josselyn E. Garcia-Perez, Liston A., Meyts I., Rodriguez P.D., Schjerven H., Schlenner S.M., van der Burg M., Van Nieuwenhove E., van Schouwenburg P.A., Verhoeyen E., Wouters C.H.Fuentes:scopusAuthor Correction: The cellular composition of the human immune system is shaped by age and cohabitation (Nature Immunology, (2016), 17, 4, (461-468), 10.1038/ni.3371)
OtherAbstract: In the version of this article initially published, in the Acknowledgements, the grant number for thPalabras claves:Autores:Boeckxstaens G., Carr E.J., Dooley J., Goris A., Josselyn E. Garcia-Perez, Lagou V., Lee J.C., Linterman M.A., Liston A., Meyts I., Wouters C.H.Fuentes:scopusImmunologic profiles of multiple sclerosis treatments reveal shared early B cell alterations
ArticleAbstract: Objective: We undertook a systems immunology approach of the adaptive immune system in multiple sclePalabras claves:Autores:Danso-Abeam D., de Muynck L., Decallonne B., Dooley J., Dubois B., Franckaert D., Goris A., Hilven K., Josselyn E. Garcia-Perez, Liston A., Nguyen A.T.L., Pauwels I., Smets I., Terbeek J.Fuentes:scopusPsychological comorbidity increases the risk for postinfectious IBS partly by enhanced susceptibility to develop infectious gastroenteritis
ArticleAbstract: Objective Psychological factors increase the risk to develop postinfectious IBS (PI-IBS), but the mePalabras claves:IgE, Irritable bowel syndromeAutores:Aguilera-Lizarraga J., Boeckxstaens G., Dooley J., Josselyn E. Garcia-Perez, Liston A., Nguyen A.T.L., Van Brabant W., Van Oudenhove L., Van Ranst M., Van Wanrooy S., Verhaegen J., Wouters M.M.Fuentes:scopusThe cellular composition of the human immune system is shaped by age and cohabitation
ArticleAbstract: Detailed population-level description of the human immune system has recently become achievable. WePalabras claves:Autores:Boeckxstaens G., Carr E.J., Dooley J., Goris A., Josselyn E. Garcia-Perez, Lagou V., Lee J.C., Linterman M.A., Liston A., Meyts I., Wouters C.H.Fuentes:scopusThe microRNA-29 family dictates the balance between homeostatic and pathological glucose handling in diabetes and obesity
ArticleAbstract: The microRNA-29 (miR-29) family is among the most abundantly expressed microRNA in the pancreas andPalabras claves:Autores:De Strooper B., Deroose C., Dooley J., Josselyn E. Garcia-Perez, Liston A., Mathieu C., McGuinness O.P., Papadopoulou A.S., Schlenner S.M., Schönefeldt S., Serneels L., Sreenivasan J., Staats K.A., Tian L., Van Der Schueren B., Vangoitsenhoven R.Fuentes:scopusMultiple sclerosis risk variants alter expression of co-stimulatory genes in B cells
ArticleAbstract: The increasing evidence supporting a role for B cells in the pathogenesis of multiple sclerosis promPalabras claves:B cells, CD40, CD86, Multiple Sclerosis, susceptibilityAutores:Ban M., Coles A.J., Compston A., Dooley J., Dubois B., Fiddes B., Goris A., He D., Humblet-Baron S., Jones J., Josselyn E. Garcia-Perez, Liao W., Liston A., Mallants K., Sawcer S., Smets I., Wang G.Fuentes:scopus