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3-Nitropropionic acid activates calpain/cdk5 pathway in rat striatum
ArticleAbstract: 3-Nitropropionic acid (3-NP) is a neurotoxin that inhibits mitochondrial complex II and is used in aPalabras claves:3-nitropropionic acid, Calpain, CDK5, MEF2Autores:Antoni Camins, Canudas A.M., Crespo-Biel N., Pallás M., Pelegrí Gabalda C., Vilaplana J.Fuentes:scopusCalpains as a target for therapy of neurodegenerative diseases: Putative role of lithium
ReviewAbstract: Lithium is a simple cation that has been used clinically since 1950 for the treatment of bipolar disPalabras claves:apoptosis, Calcium homeostasis, Calpain, Cell cycle control, Cytoskeleton, DNA damage, Kinases, Lithium, Neurodegeneration, neurodegenerative diseases, signal transduction, Tau kinasesAutores:Antoni Camins, Canudas A.M., Crespo-Biel N., Junyent F., Pallás M., Verdaguer E.Fuentes:scopusEvidence of calpain/cdk5 pathway inhibition by lithium in 3-nitropropionic acid toxicity in vivo and in vitro
ArticleAbstract: Lithium reduced striatal neurodegeneration induced in rats by 3-nitropropionic acid inhibiting calpaPalabras claves:3-nitropropionic acid, calcium, Calpain, Lithium, Neurodegenerative Disease, P35, SpectrinAutores:Antoni Camins, Canudas A.M., Crespo-Biel N., Pallás M.Fuentes:scopusKainate induces AKT, ERK and cdk5/GSK3β pathway deregulation, phosphorylates tau protein in mouse hippocampus
ArticleAbstract: Acute treatment with kainate 30 mg/kg (KA) produced behavioral alterations and reactive gliosis. HowPalabras claves:Akt, Calpain, CDK5, GSK3β, Tau phosphorylationAutores:Antoni Camins, Canudas A.M., Crespo-Biel N., Pallás M.Fuentes:scopusKainate-induced toxicity in the hippocampus: Potential role of lithium
ArticleAbstract: Objectives: We investigated the neuroprotective effects of lithium in an experimental neurodegeneratPalabras claves:calcium, Calpain, CDK5, Excitotoxicity, GSK-3, P35Autores:Antoni Camins, Canudas A.M., Crespo-Biel N., Pallás M.Fuentes:scopus