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An overview of investigational antiapoptotic drugs with potential application for the treatment of neurodegenerative disorders
ReviewAbstract: Importance of the field: The increase in life expectancy in developed countries has given rise to sePalabras claves:Alzheimer's disease, apoptosis, Neuroprotective drugs, Parkinson's DiseaseAutores:Antoni Camins, Folch J., Junyent F., Pallás M., Sureda F.X., Verdaguer E., Zárate C.B.Fuentes:scopusAntiapoptotic drugs: A therapautic strategy for the prevention of neurodegenerative diseases
ReviewAbstract: The purpose of this review is to discuss potential pathways involved in the pathogenesis of neurodegPalabras claves:Alzheimer's disease, apoptosis, Cyclin-dependent kinases, Glutamate receptors, Neuronal cell death, Neuroprotective drugs. apoptosis, Parkinson's DiseaseAutores:Antoni Camins, Auladell C., Canudas A.M., Folch J., Junyent F., Pallás M., Pelegrí Gabalda C., Sureda F.X., Verdaguer E., Vilaplana J., Zárate C.B.Fuentes:scopusA molecular study of pathways involved in the inhibition of cell proliferation in neuroblastoma B65 cells by the GSK-3 inhibitors lithium and SB-415286
ArticleAbstract: Pharmacological GSK-3 inhibitors are potential drugs for the treatment of neurodegenerative diseasesPalabras claves:apoptosis, B65 cells, Cdc2, GSK3, Lithium, SB-415286Autores:Antoni Camins, Esparza J.L., Folch J., Jordan J., Pallás M., Pizarro J.G.Fuentes:scopusDNA low-density array analysis of colchicine neurotoxicity in rat cerebellar granular neurons
ArticleAbstract: Cytoskeletal alteration is a key factor in neurodegenerative processes like Alzheimer's or ParkinsonPalabras claves:Acute toxicity, apoptosis, caspase, cell cycle, Cerebellar granule neurons, colchicine, Oxidative StressAutores:Alvira D., Antoni Camins, Folch J., Forsby A., Pallás M., Rimbau V., Sureda F.X., Yeste-Velasco M.Fuentes:scopusATM is involved in cell-cycle control through the regulation of retinoblastoma protein phosphorylation
ArticleAbstract: Ataxia telangiectasia mutated protein (ATM) is a member of the phosphatidylinositol-3 kinase (PI3K)Palabras claves:apoptosis, ATM, cell cycle, KU-55933, Retinoblastoma protein, siRNAAutores:Antoni Camins, de la Torre A.V., Folch J., Jordan J., Junyent F., Pallás M., Pizarro J.G., Verdaguer E.Fuentes:scopusActivation of ataxia telangiectasia muted under experimental models and human Parkinson's disease
ArticleAbstract: In the present study we demonstrated that neurotoxin MPP +-induced DNA damage is followed by ataxiaPalabras claves:apoptosis, ATM, B65 neuroblastoma, cell cycle, MPP +, Parkinson's Disease, Retinoblastoma proteinAutores:Alvira D., Antoni Camins, de la Torre A.V., Ferrer I., Folch J., Gutiérrez-Cuesta J., Jordan J., Junyent F., Pallás M., Pizarro J.G., Sureda F.X., Verdaguer E.Fuentes:scopusGSK-3β inhibition and prevention of mitochondrial apoptosis inducing factor release are not involved in the antioxidant properties of SB-415286
ArticleAbstract: The antioxidant effects of lithium and SB-415286, two glycogen synthase kinase-3β (GSK-3β) inhibitorPalabras claves:AIF, apoptosis, GSK-3β, Lithium, Oxidative Stress, SB-415286Autores:Antoni Camins, Folch J., Jiménez A., Pallás M., Rimbau V., Yeste-Velasco M.Fuentes:scopusGSK3β inhibition is involved in the neuroprotective effects of cyclin-dependent kinase inhibitors in neurons
ArticleAbstract: In the present study, we evaluated the effects of roscovitine (Rosco) and flavopiridol (Flavo), bothPalabras claves:apoptosis, Cerebellar granular cells, flavopiridol, GSK3β, RoscovitineAutores:Antoni Camins, Auladell C., de la Torre A.V., Folch J., Junyent F., Pallás M., Pelegrí Gabalda C., Verdaguer E., Vilaplana J., Zárate C.B.Fuentes:scopusGlycogen synthase kinase-3 is involved in the regulation of the cell cycle in cerebellar granule cells
ArticleAbstract: Recent studies have demonstrated that neuronal reentry in the cell cycle and specifically the expresPalabras claves:apoptosis, cell cycle, Cerebellar granule cells, GSK3β, Lithium, SB415286, Serum and potassium withdrawalAutores:Abad M.A., Antoni Camins, Enguita M., Folch J., Pallás M., Trullàs R., Yeste-Velasco M.Fuentes:scopusEvaluation of hypoxia inducible factor expression in inflammatory and neurodegenerative brain models
ArticleAbstract: The neuroinflammatory process is thought to contribute to the progression of neurological disordersPalabras claves:Alzheimer's, apoptosis, APP/PS1, c-Jun, HIF-1αAutores:Antoni Camins, Auladell C., Brox S., de la Torre A.V., De Lemos M.L., Folch J., Lazarowski A., Pallás M., Petrov D., Zárate C.B.Fuentes:scopus