Mostrando 10 resultados de: 10
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Endocrinology(3)
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scopus(10)
Cofactors, redox state, and directional preferences of hydroxysteroid dehydrogenases
ReviewAbstract: The hydroxysteroid dehydrogenases (HSDs) interconvert pairs of weak and potent steroids, thus servinPalabras claves:androgen, Equilibrium, Estrogen, Glucocorticoid, Hydroxysteroid dehydrogenase, Nicotinamide cofactor, Redox stateAutores:Agarwal A.K., Andersson S., Brandmaier A., Chattopadhyay A., Khan N., Papari-Zareei M., Rambally S., Richard J. Auchus, Sharma K.K., Sherbet D.P.Fuentes:scopusCombined 17α-hydroxylase/17,20-lyase deficiency due to p.R96W mutation in the CYP17 gene in a Brazilian patien
ArticleAbstract: Congenital adrenal hyperplasia (CAH) resulting from 17α-hydroxylase/17,20-lyase deficiency is a rarePalabras claves:Autores:Costenaro F., Czepielewski M., Kater C.E., Papari-Zareei M., Richard J. Auchus, Rodrigues T.Fuentes:scopusBiochemical factors governing the steady-state estrone/estradiol ratios catalyzed by human 17β-hydroxysteroid dehydrogenases types 1 and 2 in HEK-293 cells
ArticleAbstract: Human 17β-hydroxysteroid dehydrogenase types 1 and 2 (17βHSD1 and 17βHSD2) regulate estrogen potencyPalabras claves:Autores:Akbar S., Guryev O.L., Mizrachi D., Papari-Zareei M., Rambally S., Richard J. Auchus, Sherbet D.P.Fuentes:scopus3β-hydroxysteroid dehydrogenase is a possible pharmacological target in the treatment of castration-resistant prostate cancer
ArticleAbstract: Prostate cancer usually responds to androgen deprivation therapy, although the response in metastatiPalabras claves:Autores:Evaul K., Li R., Papari-Zareei M., Richard J. Auchus, Sharifi N.Fuentes:scopusA novel point mutation in P450c17 (CYP17) causing combined 17α-hydroxylase/17,20-lyase deficiency
ArticleAbstract: Context: Combined 17α-hydroxylase/17,20-lyase deficiency is a rare cause of congenital adrenal hyperPalabras claves:Autores:Achermann J.C., Ahmad T., Brooke A.M., Gore M.E., Lin L., Monson J.P., Papari-Zareei M., Richard J. Auchus, Rumsby G., Shepherd J.H., Taylor N.F.Fuentes:scopusArginine 276 controls the directional preference of AKR1C9 (rat liver 3α-hydroxysteroid dehydrogenase) in human embryonic kidney 293 cells
ArticleAbstract: Rat liver AKR1C9 is the best-studied 3α-hydroxysteroid dehydrogenase (3αHSD) of the aldo-keto reductPalabras claves:Autores:Brandmaier A., Papari-Zareei M., Richard J. AuchusFuentes:scopusDihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer
ArticleAbstract: In the majority of cases, advanced prostate cancer responds initially to androgen deprivation therapPalabras claves:5-alpha-androstanedione, Abiraterone acetate, Hormonal therapy, Hormone resistance, Tumor metabolismAutores:Chang K.H., Li R., Papari-Zareei M., Richard J. Auchus, Sharifi N., Watumull L., Zhao Y.Fuentes:scopusPhenotypic variation in a Chinese family with 46,XY and 46,XX 17α-hydroxylase deficiency
ArticleAbstract: Background: 17α-hydroxylase deficiency is a rare autosomal recessive disorder characterized by sexuaPalabras claves:17α-hydroxylase deficiency, CYP17A1 gene, Cytochrome P450c17, Mutational analysis, phenotypic variationAutores:Bee Y.M., Manju C., Papari-Zareei M., Richard J. AuchusFuentes:scopusTwo novel mutations found in a patient with 17α-hydroxylase enzyme deficiency
ArticleAbstract: Context: Congenital adrenal hyperplasia resulting from 17α- hydroxylase deficiency (17OHD) is a rarePalabras claves:Autores:Ergun-Longmire B., New M., Papari-Zareei M., Richard J. Auchus, Tansil S., Wilson R.Fuentes:scopusPuberty in a case with novel 17-hydroxylase mutation and the putative role of estrogen in development of pubic hair
ArticleAbstract: Objective: 17-Hydroxylase/17,20-lyase deficiency (17OHD) results from mutations in the CYP17A1 gene,Palabras claves:Autores:Akcay T., Bereket A., Guran T., Papari-Zareei M., Richard J. Auchus, Turan S.Fuentes:scopus