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Clinical and biochemical consequences of CYP17A1 inhibition with abiraterone given with and without exogenous glucocorticoids in castrate men with advanced prostate cancer
ArticleAbstract: Context: Abiraterone acetate is a small-molecule cytochrome P450 17A1 (CYP17A1) inhibitor that is acPalabras claves:Autores:Arlt W., Attard G., Cassidy A.M., De Bono J.S., Dowsett M., Folkerd E., Hughes B.A., Oommen N.B., Reid A.H.M., Richard J. Auchus, Thompson E.Fuentes:scopusThiazolidinediones but Not Metformin Directly Inhibit the Steroidogenic Enzymes P450c17 and 3β-Hydroxysteroid Dehydrogenase
ArticleAbstract: Androgen biosynthesis requires 3β-hydroxysteroid dehydrogenase type II (3βHSDII) and the 17α-hydroxyPalabras claves:Autores:Arlt W., Miller W.L., Richard J. AuchusFuentes:scopus