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Toxicon(4)
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Biological and biochemical characterization of new basic phospholipase A<inf>2</inf> BmTX-I isolated from Bothrops moojeni snake venom
ArticleAbstract: BmTX-I, an Asp49 phospholipase A2, was purified from Bothrops moojeni venom after only one chromatogPalabras claves:Asp49 phospholipase A2, characterization, Edema-forming activity, Myonecrosis and interleukin-6 response, Neuromuscular blockade, Snake venomAutores:Baldasso P.A., Calgarotto A.K., Damico D.C.S., Eberlin M.N., Marangoni S., Ponce-Soto L.A., Saulo L. Silva, Souza G.H.M.F.Fuentes:scopusA multivariate study on flavonoid compounds scavenging the peroxynitrite free radical
ArticleAbstract: The goal of this study is to select electronic properties (variables or descriptors) responsible forPalabras claves:flavonoids, Free radicals, HCA, Knn, pattern recognition, PCa, PeroxinitriteAutores:Calgarotto A.K., Comar M., Da Silva A.B.F., Honório K.M., Marangoni S., Miotto S., Oliveira K.M.T., Saulo L. Silva, Silva J.L.Fuentes:scopusDifferential effects of nitrostyrene derivatives on myelopoiesis involve regulation of C/EBPα and p38MAPK activity
ArticleAbstract: Bone marrow failure syndromes and MDS represent a heterogenous group of diseases, characterized by iPalabras claves:Autores:Bartels M., Bierings M.B., Calgarotto A.K., Coffer P.J., De Souza Queiroz M.L., Martens A.C., Maso V., Saulo L. SilvaFuentes:scopusMolecular modeling and inhibition of phospholipase A<inf>2</inf> by polyhydroxy phenolic compounds
ArticleAbstract: Phospholipases A2 are enzymes responsible for the hydrolysis of membrane phospholipids that releasePalabras claves:DFT, Enzymatic kinetics, molecular modeling, PHENOLIC COMPOUNDS, PLA 2Autores:Baldasso P.A., Calgarotto A.K., Comar M., Damico D.C.S., Marangoni S., Maso V., Oliveira A.R.M., Oliveira K.M.T., Saulo L. Silva, Veber C.L., Villar J.A.F.P.Fuentes:scopusMolecular modeling of the inhibition of enzyme PLA<inf>2</inf> from snake venom by dipyrone and 1-phenyl-3-methyl-5-pyrazolone
Conference ObjectAbstract: Phospholipases A2 (PLA2) are enzymes that trigger the degradation cascade of the arachidonic acid, lPalabras claves:DFT, Dipyrone, molecular modeling, OPLS, PLA 2Autores:Baldasso P.A., Bezerra E.R.M., Calgarotto A.K., Chaar J.S., Comar M., Marangoni S., Oliveira A.R.M., Oliveira K.M.T., Saulo L. Silva, Veber C.L., Villar J.A.F.P.Fuentes:scopusPharmacological study of edema and myonecrosis in mice induced by venom of the bushmaster snake (Lachesis muta muta) and its basic Asp49 phospholipase A<inf>2</inf> (LmTX-I)
ArticleAbstract: Previous in vitro studies show that Lachesis muta venom and its purified Asp49 phospholipase A2, namPalabras claves:EDEMA, inflammation, Lachesis m. muta, Myotoxicity, Phospholipase A 2Autores:Calgarotto A.K., Cintra M., Da Cruz Höfling M.A., Damico D.C.S., Leonardo M.B., Marangoni S., Saulo L. SilvaFuentes:scopusIsolation and characterization of ellagic acid derivatives isolated from Casearia sylvestris SW aqueous extract with anti-PLA<inf>2</inf> activity
ArticleAbstract: The Casearia sylvestris SW (Flacourtiaceae) is utilized in folk medicine (Brazil and all Latin AmeriPalabras claves:Bothrops jararacussu, Casearia sylvestris, Ellagic acid, Enzymatic activity, PLA 2Autores:Calgarotto A.K., Chaar J.S., Marangoni S., Saulo L. SilvaFuentes:scopusKoninginins, phospholipase A<inf>2</inf> inhibitors from endophytic fungus Trichoderma koningii
ArticleAbstract: Many isolated compounds from endophytic fungus have been useful to human beings, mainly those with mPalabras claves:Bothrops, Koninginin, Myotoxicity, Phospholipase A 2, PLA 2, TRICHODERMAAutores:Calgarotto A.K., Marangoni S., Maso V., Pereira J.O., Rodrigues-Filho E., Saulo L. Silva, Souza A.D.L., Souza A.Q.L.Fuentes:scopusSynthesis and evaluation of nitrostyrene derivative compounds, new snake venom phospholipase A<inf>2</inf> inhibitors
ArticleAbstract: Several nitrostyrene derivatives were synthesized and their inhibitive activities on phospholipase APalabras claves:Bothrops jararacussu, Chemometrics, DFT, Nitrostyrene, PLA 2Autores:Calgarotto A.K., Lima F.T.D., Marangoni S., Oliveira A.R.M., Saulo L. Silva, Veber C.L., Villar J.A.F.P.Fuentes:scopus