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Diversity and bias through receptor-receptor interactions in GPCR heteroreceptor complexes. Focus on examples from dopamine D2 receptor heteromerization
ReviewAbstract: Allosteric receptor-receptor interactions in GPCR heteromers appeared to introduce an intermolecularPalabras claves:allosteric modulation, Biased recognition, Biased signaling, G protein-coupled receptor, Heterodimerization, Receptor diversity, Receptor heterodimers, Receptor-receptor interactionsAutores:Agnati L.F., Borroto-Escuela D.O., Díaz-Cabiale Z., Ferraro L., Filip M., Fuxe K., Garriga P., Tanganelli S., Tarakanov A.O., W. Romero-FernandezFuentes:scopusGPCR heteromers and their allosteric receptor-receptor interactions
ArticleAbstract: The concept of intramembrane receptor-receptor interactions and evidence for their existences were iPalabras claves:Adenosine receptor, allosteric modulation, Dopamine receptors, GPCR, moonlighting, Oligomers, Receptor G protein coupling, Receptor interface, Receptor mosaic, Receptor recognition, Receptor signaling, Receptor trafficking, Triplet homologiesAutores:Agnati L.F., Borroto-Escuela D.O., Ciruela F., Ferraro L., Filip M., Frankowska M., Fuxe K., Guidolin D., Marcellino D., Tanganelli S., Tarakanov A.O., W. Romero-Fernandez, Woods A.S.Fuentes:scopusOSU-6162, a Sigma1R Ligand in Low Doses, Can Further Increase the Effects of Cocaine Self-Administration on Accumbal D2R Heteroreceptor Complexes
ArticleAbstract: Cocaine was previously shown to act at the Sigma1R which is a target for counteracting cocaine actioPalabras claves:A2AR-D2R heteroreceptor complexes, allosteric receptor-receptor interactions, cocaine use disorder, monoamine stabilizerAutores:Borroto-Escuela D.O., Filip M., Fuxe K., Suder A., W. Romero-Fernandez, Wydra K., Zhou Z.Fuentes:scopusThe Balance of MU-Opioid, Dopamine D2 and Adenosine A2A Heteroreceptor Complexes in the Ventral Striatal-Pallidal GABA Antireward Neurons May Have a Significant Role in Morphine and Cocaine Use Disorders
ArticleAbstract: The widespread distribution of heteroreceptor complexes with allosteric receptor-receptor interactioPalabras claves:Adenosine A2A receptor, cocaine use disorder, dopamine D2 receptor, G protein-coupled receptor, morphine use disorder, mu opioid receptor, oligomerization, morphineAutores:Beggiato S., Borroto-Escuela D.O., Crespo-Ramirez M., Ferraro L., Filip M., Fores-Pons R., Frankowska M., Fuxe K., Perez de la Mora M., Rivera A., Rocha L.L., Stove C., Vasudevan L., W. Romero-Fernandez, Wydra K.Fuentes:scopus