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Farmacología y terapéutica(2)
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Acute cocaine treatment enhances the antagonistic allosteric adenosine A2A-dopamine D2 receptor–receptor interactions in rat dorsal striatum without increasing significantly extracellular dopamine levels
ArticleAbstract: Background: Antagonistic adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R) receptor–receptorPalabras claves:Adenosine A2A receptor, Cocaine, dopamine D2 receptor, Heteroreceptor complexes, Sigma1 receptorAutores:Beggiato S., Borroto-Escuela D.O., Ferraro L., Filip M., Fuxe K., Tanganelli S., W. Romero-Fernandez, Wydra K., Zhou Z.Fuentes:scopusOSU-6162, a Sigma1R Ligand in Low Doses, Can Further Increase the Effects of Cocaine Self-Administration on Accumbal D2R Heteroreceptor Complexes
ArticleAbstract: Cocaine was previously shown to act at the Sigma1R which is a target for counteracting cocaine actioPalabras claves:A2AR-D2R heteroreceptor complexes, allosteric receptor-receptor interactions, cocaine use disorder, monoamine stabilizerAutores:Borroto-Escuela D.O., Filip M., Fuxe K., Suder A., W. Romero-Fernandez, Wydra K., Zhou Z.Fuentes:scopus