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Artemisinin-based antimalarial research: application of biotechnology to the production of artemisinin, its mode of action, and the mechanism of resistance of Plasmodium parasites
ReviewAbstract: Malaria is a worldwide disease caused by Plasmodium parasites. A sesquiterpene endoperoxide artemisiPalabras claves:Artemisia annua, Artemisinin, MALARIA, Metabolic engineering, Mode of action, Resistant parasitesAutores:Ery Odette Fukushima, Muangphrom P., Muranaka T., Seki H.Fuentes:googlescopusFunctional analysis of amorpha-4,11-diene synthase (ADS) homologs from non-artemisinin-producing artemisia species: The discovery of novel koidzumiol and (+)-a-Bisabolol synthases
ArticleAbstract: The production of artemisinin, the most effective antimalarial compound, is limited to Artemisia annPalabras claves:(+)-a-Bisabolol, Amorpha-4,11-diene synthase, ARTEMISIA ABSINTHIUM, Artemisia kurramensis, Artemisia maritime, KoidzumiolAutores:Ery Odette Fukushima, Komori A., Mikawa R., Muangphrom P., Muranaka T., Nishiwaki M., Seki H., Suzuki M.Fuentes:googlescopusFunctional analysis of orthologous artemisinic aldehyde Δ11(13)-reductase reveals potential artemisinin-producing activity in non-artemisinin-producing Artemisia absinthium
ArticleAbstract: Artemisinin is the most effective antimalarial compound isolated from Artemisia annua. Artemisinic aPalabras claves:ARTEMISIA ABSINTHIUM, Artemisinin, DBR2 ortholog, Dihydroartemisinic aldehyde, ReductaseAutores:Ery Odette Fukushima, Muangphrom P., Muranaka T., Seki H., Suzuki M.Fuentes:googlescopusIdentification and characterization of a novel sesquiterpene synthase, 4-amorphen-11-ol synthase, from artemisia maritima
ArticleAbstract: Artemisinin, a sesquiterpene lactone exhibiting effective antimalarial activity, is produced by onlyPalabras claves:4-amorphen-11-ol, 4-amorphen-11-ol synthase, Artemisia maritima, Artemisinin, Sesquiterpene synthaseAutores:Ery Odette Fukushima, Matsumoto S., Muangphrom P., Muranaka T., Nishiwaki M., Seki H.Fuentes:googlescopus