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Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage
ReviewAbstract: Placental and fetal hypoxia caused by perinatal hypoxic-ischemic events are major causes of stillbirPalabras claves:Biomarker, DNA methylation, histone modifications, Hypoxia, hypoxic-ischemic encephalopathy, ischemia, microRNAsAutores:Antonio Wenceslao Danilo Gavilanes, Barkhuizen M., Bruno M.A., Bustelo M., Loidl C.F., Steinbusch H.W.M., van den Hove D.L.A.Fuentes:scopusBrain apoptosis and carotid artery reactivity in fetal asphyctic preconditioning
ArticleAbstract: We aimed to develop a model of fetal hypoxia-ischemia (HI) preconditioning that reflects the pathophPalabras claves:apoptosis, Carotid reactivity, Fetal asphyxia, Perinatal asphyxia, preconditioningAutores:Antonio Wenceslao Danilo Gavilanes, Blanco C.E., Steinbusch H., Steinbusch H.W.M., Strackx E., van den Hove D.L.A., Villamor E., Vles J.S.H., Zoer B.Fuentes:scopus25 years of research on global asphyxia in the immature rat brain
ReviewAbstract: Hypoxic-ischemic encephalopathy remains a common cause of brain damage in neonates. Preterm infantsPalabras claves:Encephalopathy, functional outcome, Hypoxic-ischemia, Preterm infant, SubmersionAutores:Antonio Wenceslao Danilo Gavilanes, Barkhuizen M., Kramer B.W., Steinbusch H.W.M., van den Hove D.L.A., Vles J.S.H.Fuentes:scopusA combined behavioral and morphological study on the effects of fetal asphyxia on the nigrostriatal dopaminergic system in adult rats
ArticleAbstract: Fetal asphyxic insults in the brain are known to be associated with developmental neurological problPalabras claves:dopamine, Fetal asphyxia, Glial fibrillary acidic protein (GFAP), locomotion, Open field, RAT, Striatum, Substantia nigra, Tyrosine hydroxylase (TH), VentriculomegalyAutores:Antonio Wenceslao Danilo Gavilanes, Blanco C.E., Steinbusch H., Steinbusch H.W.M., Strackx E., van den Hove D.L.A., Vles J.S.H.Fuentes:scopusFetal asphyctic preconditioning protects against perinatal asphyxia- induced apoptosis and astrogliosis in neonatal brain
ArticleAbstract: Hypoxic-ischemic preconditioning is an endogenous mechanism in which exposure to a sublethal episodePalabras claves:apoptosis, Astrogliosis, Fetal preconditioning, Hypoxia-ischemia, Neonatal brain, Perinatal asphyxiaAutores:Antonio Wenceslao Danilo Gavilanes, Cox-Limpens K.E.M., de Jong M., Steinbusch H.W.M., Strackx E., van den Hove D.L.A., van Ekkendonk J.R.A., Vles J.S.H., Zimmermann L.J.I.Fuentes:scopusFetal asphyxia leads to a decrease in dorsal raphe serotonergic neurons
ArticleAbstract: The aim of the present study was to determine the effects of fetal asphyxia (FA) on anxiety and seroPalabras claves:5-Hydroxytryptamine/serotonin, anxiety, Dorsal raphe nucleus, Fetal asphyxia, Rat brain, agingAutores:Antonio Wenceslao Danilo Gavilanes, Blanco C.E., Prickaerts J., Steinbusch H., Steinbusch H.W.M., Strackx E., van den Hove D.L.A., Vles J.S.H.Fuentes:scopusFetal asphyxia leads to the loss of striatal presynaptic boutons in adult rats
ArticleAbstract: Fetal asphyxic insults in the brain are known to be associated with developmental and neurological pPalabras claves:aging, Fetal asphyxia, Neurodegenerative disorders, Synapse, synaptophysinAutores:Antonio Wenceslao Danilo Gavilanes, Blanco C.E., Steinbusch H., Steinbusch H.W.M., Strackx E., van den Hove D.L.A., Vles J.S.H.Fuentes:scopusStatistical differences resulting from selection of stable reference genes after hypoxia and hypothermia in the neonatal rat brain
ArticleAbstract: Real-time reverse transcription PCR (qPCR) normalized to an internal reference gene (RG), is a frequPalabras claves:Autores:Antonio Wenceslao Danilo Gavilanes, Bruno M.A., Bustelo M., Loidl C.F., Rey-Funes M., Steinbusch H.W.M., van den Hove D.L.A.Fuentes:scopusSystemic multipotent adult progenitor cells improve long-term neurodevelopmental outcomes after preterm hypoxic-ischemic encephalopathy
ArticleAbstract: There is an urgent need for therapies that could reduce the disease burden of preterm hypoxic-ischemPalabras claves:hypoxic-ischemic encephalopathy, Neurodevelopment, Preterm brain, Stem cell therapyAutores:Antonio Wenceslao Danilo Gavilanes, Barkhuizen M., Kramer B.W., Mays R.W., Paes D., Peter A. Chedraui, Robertson N.J., Steinbusch H.W.M., Vaes B., van den Hove D.L.A., van Mechelen R., Vermeer M.Fuentes:scopus