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Memantine loaded PLGA PEGylated nanoparticles for Alzheimer's disease: In vitro and in vivo characterization
ArticleAbstract: Background: Memantine, drug approved for moderate to severe Alzheimer's disease, has not shown to bePalabras claves:Alzheimer's disease, APPswe/PS1dE9 mice, astrocytes, BEnd.3, Brain targeting, Memantine, Nanoparticles, β-Amyloid plaquesAutores:Antoni Camins, Calpena A.C., Cano A., Carmona N., Egea M.A., Espina M., Ettcheto M., García M.L., Sanchez-Lopez E., Silva A.M., Souto E.M.B.Fuentes:scopusMemantine-Loaded PEGylated Biodegradable Nanoparticles for the Treatment of Glaucoma
ArticleAbstract: Glaucoma is a multifactorial neurodegenerative disease associated with retinal ganglion cells (RGC)Palabras claves:drug delivery, glaucoma, Memantine, Nanoparticles, PLGA-PEGAutores:Antoni Camins, Calpena A.C., Cordeiro M.F., Davis B.M., Egea M.A., Espina M., Ettcheto M., García M.L., Guo L., Ravindran N., Sanchez-Lopez E., Silva A.M., Souto E.M.B.Fuentes:scopusNew potential strategies for Alzheimer's disease prevention: pegylated biodegradable dexibuprofen nanospheres administration to APPswe/PS1dE9
ArticleAbstract: Dexibuprofen loaded pegylated poly(lactic-co-glycolic) nanospheres prepared by solvent diffusion metPalabras claves:Alzheimer's disease, blood-brain barrier, Dexibuprofen, Nanoparticles, Nanospheres, PLGA-PEGAutores:Antoni Camins, Calpena A.C., Egea M.A., Espina M., Ettcheto M., Folch J., García M.L., Sanchez-Lopez E.Fuentes:scopusDevelopment of fluorometholone-loaded PLGA nanoparticles for treatment of inflammatory disorders of anterior and posterior segments of the eye
ArticleAbstract: The main objective of this study was the development and optimization of fluorometholone-loaded PLGAPalabras claves:drug delivery, Fluorometholone, Nanoparticles, Ocular anti-inflammatory, permeation, PLGAAutores:Calpena A.C., Egea M.A., Espina M., García M.L., Gonzalez-Pizarro R., Silva-Abreu M.Fuentes:scopusOptimization, Biopharmaceutical Prof ile and Therapeutic Ef f i cacy of Pi ogl i tazone-l oaded PLGA-PEG Nanospheres as a Novel Strategy for Ocular Inflammatory Disorders
ArticleAbstract: Purpose The main goal of this study was to encapsulate Pioglitazone (PGZ), in biodegradable polymeriPalabras claves:drug delivery, Nanospheres, ocular anti-inflammatory efficacy, Pioglitazone, PLGA-PEGAutores:Álvaro Gimeno, Calpena A.C., Egea M.A., Espina M., García M.L., Silva A.M., Silva-Abreu M.Fuentes:scopusBiopharmaceutical evaluation of epigallocatechin gallate-loaded cationic lipid nanoparticles (EGCG-LNs): In vivo, in vitro and ex vivo studies
ArticleAbstract: Cationic lipid nanoparticles (LNs) have been tested for sustained release and site-specific targetinPalabras claves:Draize test, Epigallocatechin gallate, HET-CAM test, lipid nanoparticles, ocular deliveryAutores:Calpena A.C., Clares-Naveros B., Egea M.A., Francisco J. Veiga, García M.L., Joana F. Fangueiro, Silva A.M., Souto E.M.B., Tatiana AndreaniFuentes:scopusPioglitazone Loaded-PLGA-PEG Nanoparticles: Drug Release and Interactions
OtherAbstract: Introduction The main obstacle to transport drugs to the brain, for neurodegenerative diseases treatPalabras claves:Autores:Calpena A.C., Egea M.A., Espina M., García M.L., Marcelle Silva de Abreu, Maria Luisaía GarcFuentes:scopusDesign and elaboration of freeze-dried PLGA nanoparticles for the transcorneal permeation of carprofen: Ocular anti-inflammatory applications
ArticleAbstract: This work aimed the design and development of poly(lactic-co-glycolic) acid (PLGA) nanoparticles (NPPalabras claves:carprofen, Eye surgery, Factorial design, Freeze-drying, Nanoparticles, PLGAAutores:Alexander Parra, Calpena A.C., Clares-Naveros B., Egea M.A., Espina M., García M.L., Mallandrich M.Fuentes:scopusPermeation studies through porcine small intestine of furosemide solutions for personalised paediatric administration
ArticleAbstract: Personalized medicine is a challenging research area in paediatric drug design since no suitable phaPalabras claves:Furosemide, Intestinal permeation, Oral solution, Paediatric designAutores:Aroha B. Sánchez, Calpena A.C., Clares-Naveros B., Egea M.A., Mallandrich M., Nora ProvenzaFuentes:scopusValidation of a high performance liquid chromatography method for the stabilization of epigallocatechin gallate
ArticleAbstract: Epigallocatechin gallate (EGCG) is a green tea catechin with potential health benefits, such as antiPalabras claves:Catechins, Epigallocatechin gallate (EGCG), Reverse phase high performance liquid chromatography (RP-HPLC), validationAutores:Alexander Parra, Calpena A.C., Egea M.A., García M.L., Joana F. Fangueiro, Silva A.M., Souto E.M.B.Fuentes:scopus