Mostrando 5 resultados de: 5
Filtros aplicados
Subtipo de publicación
Article(5)
Publisher
Parasitology Research(2)
Bioorganic and Medicinal Chemistry(1)
Journal of Applied Toxicology(1)
QSAR and Combinatorial Science(1)
Área temáticas
Farmacología y terapéutica(4)
Bioquímica(1)
Ecología(1)
Enfermedades(1)
Fisiología y materias afines(1)
Área de conocimiento
Descubrimiento de fármacos(2)
Farmacología(2)
Parasitología(2)
Biología molecular(1)
Infección(1)
Origen
google(4)
Biological assay of a novel quinoxalinone with antimalarial efficacy on Plasmodium yoelii yoelii
ArticleAbstract: Compound 1-methyl-7-nitro-4-(5-(piperidin-1-yl)pentyl)-3,4- dihydroquinoxalin-2(1H)-one (VAM2-6) wasPalabras claves:Autores:Arán V.J., Malagón F., Martínez C., Rivera N., Yovani Marrero-PonceFuentes:googlescopusAntiprotozoan lead discovery by aligning dry and wet screening: Pbkp_rediction, synthesis, and biological assay of novel quinoxalinones
ArticleAbstract: Protozoan parasites have been one of the most significant public health problems for centuries and sPalabras claves:Antimalarial, Antiprotozoan database, Antitoxoplasma, antitrichomonas, Antitrypanosomal, classification model, Cytotoxicity, In silico study, In vitro assay, Leishmanicide, Machine learning-based QSAR, Non-stochastic and stochastic linear indices, ToMoCoMD-CARDD softwareAutores:Arán V.J., Cabrera-Serra M.G., Chicharro R., García-Domenech R., García-Sánchez R.N., García-Trevijano J.A.E., Gómez-Barrio A., Ibarra-Velarde F., López-Arencibia A., Lorenzo-Morales J., Machado-Tugores Y., Martín-Navarro C., Martínez-Fernández A.R., Martins Alho M.A., Meneses-Marcel A., Mondragón M., Mondragón R., Montero-Torres A., Nogal-Ruiz J.J., Pérez-Giménez F., Piñero J.E., Rivera N., Rolón M.S., Stephen Jones Barigye, Tytgat J., Vega M.C., Yovani Marrero-PonceFuentes:scopusA new type of quinoxalinone derivatives affects viability, invasion, and intracellular growth of Toxoplasma gondii tachyzoites in vitro
ArticleAbstract: Quinoxalinone derivatives, identified as VAM2 compounds (7-nitroquinoxalin-2-ones), were evaluated aPalabras claves:Apicomplexan, In silico drug design, Pellicle, Quinoxalinone derivatives, ToMoCoMD-CARDD, Toxoplasma gondiiAutores:Arán V.J., Castro Elizalde K.N., Gómez de León C.T., González Pozos S., Martins Alho M.A., Mondragón Castelán M., Mondragón R., Ramírez Flores C.J., Ricardo M.G., Rivera N., Yovani Marrero-PonceFuentes:googlescopusDiscovery of novel trichomonacidals using LDA-driven QSAR models and bond-based bilinear indices as molecular descriptors
ArticleAbstract: Few years ago, the World Health Organization estimated the number of adults with trichomoniasis at 1Palabras claves:Bond-based bilinear indices, LDA-Based QSAR Model, lead generation, ToMoCoMD-CARDD software, TrichomonacidalAutores:Alho M.A.M., Arán V.J., García-Trevijano J.A.E., Gómez-Barrio A., Huesca-Guillén A., Ibarra-Velarde F., Meneses-Marcel A., Nogal-Ruiz J.J., Pereira D.M., Rivera N., Rivera-Barroto O.M., Torrens F., Vera-Montenegro Y., Vogel C., Yovani Marrero-PonceFuentes:googlescopusIn vivo genotoxicity and cytotoxicity assessment of a novel quinoxalinone with trichomonacide activity
ArticleAbstract: The compound VAM2-6 (1-methyl-7-nitro-4-(5-(piperidin-1-yl)pentyl)-3,4-dihydroquinoxalin-2(1H)-one)Palabras claves:comet assay, genotoxicity, Micronucleus, Quinoxalinone, TrichomonacideAutores:Arán V.J., Fortoul T.I., Malagón F., Rivera E., Rivera N., Rojas M., Yovani Marrero-Ponce, Zepeda A.Fuentes:googlescopus