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Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice
ArticleAbstract: The combination of the scaffolds of the cholinesterase inhibitor huprine Y and the antioxidant capsaPalabras claves:Autores:Andrisano V., Antoni Camins, Bartolini M., Brazzolotto X., Cieslikiewicz-Bouet M., Cisternas P., Colletier J.P., Coquelle N., De Simone A., Ettcheto M., Firuzi O., García M.L., Inestrosa N.C., Jean L., Muñoz-Torrero D., Nachon F., Oliva C.A., Perez B., Pons M., Renard P.Y., Rendina M., Ricchini M., Sanchez-Lopez E., Saso L., Silman I., Viayna E.Fuentes:scopusNovel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation
ArticleAbstract: A novel series of donepezil-tacrine hybrids designed to simultaneously interact with the active, perPalabras claves:Autores:Andrisano V., Antoni Camins, Badia A., Bartolini M., Bidon-Chanal A., Camps P., Clos M.V., Estelrich J., Formosa X., Galdeano C., Gómez T., Lizondo M., Luque F.J., Mancini F., Muñoz-Torrero D., Pallás M., Scarpellini M., Viayna E.Fuentes:scopusNovel huprine derivatives with inhibitory activity toward β-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates
ArticleAbstract: A new family of dual binding site acetylcholinesterase (AChE) inhibitors has been designed, synthesiPalabras claves:Acetylcholinesterase, drug design, Inhibitors, β-amyloid peptides, β-secretaseAutores:Andrisano V., Antoni Camins, Arce M.P., Badia A., Bartolini M., Bidon-Chanal A., Camps P., Clos M.V., Galdeano C., Gómez T., Junyent F., Luque F.J., Mancini F., Muñoz-Torrero D., Pallás M., Ramírez L., Ratia M., Rodríguez-Franco M.I., Verdaguer E., Viayna E.Fuentes:scopus