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Inhibition of DNA methyltransferase leads to increased genomic 5-hydroxymethylcytosine levels in hematopoietic cells
ArticleAbstract: 5-Hydroxymethylcytosine (5hmC) is produced from 5-methylcytosine (5mC) by Ten-eleven translocation (Palabras claves:5-aza-2′-deoxycytidine, 5-hydroxymethylcytosine, 5-methylcytosine, Ascorbate, LC-MS/MSAutores:Apró A., Arányi T., Caroline Bacquet, Hathy E., Kiss J., Réthelyi J.M., Szabó P., Szeri F., Szüts D., Vető B.Fuentes:scopusTranscriptional regulation of the ABCC6 gene and the background of impaired function of missense disease-causing mutations
ReviewAbstract: The human ATP-binding cassette family C member 6 (ABCC6) gene encodes an ABC transporter protein expPalabras claves:4-phenyl-butyrate, Abcc6, C/EBPβ, Calcification, Generalized arterial calcification in infancy, HNF4α, Pseudoxanthoma elasticumAutores:Arányi T., Brampton C.N., Caroline Bacquet, de Boussac H., Fülöp K., Le Saux O., Pomozi V., Pulaski L., Ratajewski M., Váradi A.Fuentes:scopusSex-specific regulation of aging in Caenorhabditis elegans
ArticleAbstract: A fascinating aspect of sexual dimorphism in various animal species is that the two sexes differ subPalabras claves:aging, Caenorhabditis elegans, daf-16/FOXO, dauer development, insulin/IGF-1 signaling, sex determination, TRA-1/GLIAutores:Arányi T., Barna J., Bördén K., Caroline Bacquet, Hargitai B., Hotzi B., Kosztelnik M., Lippai M., Málnási-Csizmadia A., Ortutay C., Pasparaki A., Takács-Vellai K., Tavernarakis N., Vellai T.Fuentes:scopusRapid turnover of DNA methylation in human cells
ArticleAbstract: Recent studies demonstrated that cytosine methylation in the genome can be reversed without DNA replPalabras claves:5-deoxy-azacytidine, DNA methylation, TurnoverAutores:Arányi T., Caroline Bacquet, Páldi A., Szabó P., Szüts D., Yamagata Y.Fuentes:scopusThe transcriptional activity of hepatocyte nuclear factor 4 alpha is inhibited via phosphorylation by ERK1/2
ArticleAbstract: Hepatocyte nuclear factor 4 alpha (HNF4α) nuclear receptor is a master regulator of hepatocyte develPalabras claves:Autores:Arányi T., Bálint B.L., Bojcsuk D., Buday L., Caroline Bacquet, Kiss J., Martin L., Sipeki S., Vető B.Fuentes:scopus