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Activation of Akt by lithium: Pro-survival pathways in aging
ArticleAbstract: The effects of lithium on senescence were investigated using the senescence-accelerated mouse pronePalabras claves:aging, Lithium chloride, Neurodegeneration, neuroprotection, SAMP8Autores:Antoni Camins, Casadesús G., Chou S.P., Pallás M., Smith M.A., Tajes M., Yeste-Velasco M., Zhu X.Fuentes:scopusEarly amyloid accumulation in the hippocampus of SAMP8 mice
ArticleAbstract: Late-onset Alzheimer's disease (AD) is the most common form of AD appearing after 65 years of age. TPalabras claves:aging, Alzheimer's disease, Amyloid-β, Aβ40, Aβ42, AβPP, hippocampus, SAMP8, SAMR1, SenescenceAutores:Antoni Camins, Casadesús G., Del Valle J., Duran-Vilaregut J., Manich G., Pallás M., Pelegrí Gabalda C., Smith M.A., Vilaplana J.Fuentes:scopusNeuronal cell cycle re-entry markers are altered in the senescence accelerated mouse P8 (SAMP8)
ArticleAbstract: Senescence-accelerated mice 8 (SAMP8), a model of aging, display many established pathological featuPalabras claves:aging, Alzheimer's disease, CDK5, cell cycle, GSK3β, TauAutores:Antoni Camins, Casadesús G., Gutiérrez-Cuesta J., Jiménez A., Lee H.g., Ortuo-Sahagún D., Pallás M., Smith M.A., Tajes M.Fuentes:scopusNeuroprotection by c-Jun NH<inf>2</inf>-terminal kinase inhibitor SP600125 against potassium deprivation-induced apoptosis involves the Akt pathway and inhibition of cell cycle reentry
ArticleAbstract: Increasing evidence implicates the c-Jun NH2-terminal kinase (JNK) pathway in the regulation of apopPalabras claves:Akt, c-Jun NH2-terminal kinase, cell cycle, Cerebellar granule cells, SP600125Autores:Antoni Camins, Casadesús G., Folch J., Pallás M., Smith M.A., Yeste-Velasco M.Fuentes:scopusNeuroprotective effects of SB-415286 on hydrogen peroxide-induced cell death in B65 rat neuroblastoma cells and neurons
ArticleAbstract: Glycogen synthase kinase-3 (GSK-3) is involved in the pathogenesis of several neurodegenerative disePalabras claves:B65 Neuroblastoma cells, Cerebellar granule cells, H O 2 2, Lithium, Oxidative Stress, SB-415286Autores:Antoni Camins, Casadesús G., Folch J., Pallás M., Pizarro J.G., Rimbau V., Smith M.A., Yeste-Velasco M.Fuentes:scopusNeuroprotective effects of caffeine against complex I inhibition-induced apoptosis are mediated by inhibition of the ATM/p53/E2F-1 path in cerebellar granule neurons
ArticleAbstract: The aim of the present study was to evaluate the neuroprotective effects of caffeine, an inhibitor oPalabras claves:Ataxia telangiectasia mutated, caffeine, Cerebellar granule cells, Complex I inhibition, E2F-1, MPP +Autores:Alvira D., Antoni Camins, Casadesús G., Folch J., Pallás M., Smith M.A., Yeste-Velasco M.Fuentes:scopusIncreased permeability of blood-brain barrier on the hippocampus of a murine model of senescence
ArticleAbstract: SAMP8 mice show several indicative characteristics of accelerated aging and have been used to studyPalabras claves:blood-brain barrier, Confocal microscopy, hippocampus, IgG quantification, Immunohistochemistry, mouse, SAMP8, SenescenceAutores:Antoni Camins, Canudas A.M., Casadesús G., Del Valle J., Pallás M., Pelegrí Gabalda C., Smith M.A., Vilaplana J.Fuentes:scopusLow-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease
ArticleAbstract: Recent studies have implicated resveratrol and pterostilbene, a resveratrol derivative, in the protePalabras claves:aging, Alzheimer's disease, Cell signaling, COGNITION, MnSOD, NKF beta, PPAR alpha, Pterostilbene, Resveratrol, SAMP8, TauAutores:Antoni Camins, Casadesús G., Chang J., Joseph J., Pallás M., Porquet D., Reeves J., Rimando A., Shukitt-Hale B., Smith M.A.Fuentes:scopusLithium treatment decreases activities of tau kinases in a murine model of senescence
ArticleAbstract: Lithium modulates glycogen synthase kinase 3β (GSK-3β), a kinase involved in Alzheimer disease-relatPalabras claves:aging, BRAIN, Lithium, Neurodegeneration, Senescence-accelerated mouseAutores:Antoni Camins, Caballero B., Casadesús G., Ferrer I., Folch J., Gutiérrez-Cuesta J., Pallás M., Smith M.A., Tajes M.Fuentes:scopusUnveiling "the switch" from aging to Alzheimer's disease with the senescence-accelerated mouse model (SAMP8)
ReviewAbstract: Current mouse models of Alzheimer's disease (AD) are restricted to the expression of AD-related pathPalabras claves:aging, Alzheimer's disease, Amyloid-β, Animal models, COGNITION, Gliosis, Neurodegeneration, Oxidative Stress, SAMP8, Tau phosphorylationAutores:Antoni Camins, Casadesús G., Chang J., Kim H.J., Lee H.g., Pallás M., Perry G., Smith M.A., Zhu X.Fuentes:scopus