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Mechanisms of Ageing and Development(2)
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Activation of Akt by lithium: Pro-survival pathways in aging
ArticleAbstract: The effects of lithium on senescence were investigated using the senescence-accelerated mouse pronePalabras claves:aging, Lithium chloride, Neurodegeneration, neuroprotection, SAMP8Autores:Antoni Camins, Casadesús G., Chou S.P., Pallás M., Smith M.A., Tajes M., Yeste-Velasco M., Zhu X.Fuentes:scopusNeuronal cell cycle re-entry markers are altered in the senescence accelerated mouse P8 (SAMP8)
ArticleAbstract: Senescence-accelerated mice 8 (SAMP8), a model of aging, display many established pathological featuPalabras claves:aging, Alzheimer's disease, CDK5, cell cycle, GSK3β, TauAutores:Antoni Camins, Casadesús G., Gutiérrez-Cuesta J., Jiménez A., Lee H.g., Ortuo-Sahagún D., Pallás M., Smith M.A., Tajes M.Fuentes:scopusNeuroprotection by c-Jun NH<inf>2</inf>-terminal kinase inhibitor SP600125 against potassium deprivation-induced apoptosis involves the Akt pathway and inhibition of cell cycle reentry
ArticleAbstract: Increasing evidence implicates the c-Jun NH2-terminal kinase (JNK) pathway in the regulation of apopPalabras claves:Akt, c-Jun NH2-terminal kinase, cell cycle, Cerebellar granule cells, SP600125Autores:Antoni Camins, Casadesús G., Folch J., Pallás M., Smith M.A., Yeste-Velasco M.Fuentes:scopusNeuroprotective effects of caffeine against complex I inhibition-induced apoptosis are mediated by inhibition of the ATM/p53/E2F-1 path in cerebellar granule neurons
ArticleAbstract: The aim of the present study was to evaluate the neuroprotective effects of caffeine, an inhibitor oPalabras claves:Ataxia telangiectasia mutated, caffeine, Cerebellar granule cells, Complex I inhibition, E2F-1, MPP +Autores:Alvira D., Antoni Camins, Casadesús G., Folch J., Pallás M., Smith M.A., Yeste-Velasco M.Fuentes:scopusIncreased permeability of blood-brain barrier on the hippocampus of a murine model of senescence
ArticleAbstract: SAMP8 mice show several indicative characteristics of accelerated aging and have been used to studyPalabras claves:blood-brain barrier, Confocal microscopy, hippocampus, IgG quantification, Immunohistochemistry, mouse, SAMP8, SenescenceAutores:Antoni Camins, Canudas A.M., Casadesús G., Del Valle J., Pallás M., Pelegrí Gabalda C., Smith M.A., Vilaplana J.Fuentes:scopusLithium treatment decreases activities of tau kinases in a murine model of senescence
ArticleAbstract: Lithium modulates glycogen synthase kinase 3β (GSK-3β), a kinase involved in Alzheimer disease-relatPalabras claves:aging, BRAIN, Lithium, Neurodegeneration, Senescence-accelerated mouseAutores:Antoni Camins, Caballero B., Casadesús G., Ferrer I., Folch J., Gutiérrez-Cuesta J., Pallás M., Smith M.A., Tajes M.Fuentes:scopusUnveiling "the switch" from aging to Alzheimer's disease with the senescence-accelerated mouse model (SAMP8)
ReviewAbstract: Current mouse models of Alzheimer's disease (AD) are restricted to the expression of AD-related pathPalabras claves:aging, Alzheimer's disease, Amyloid-β, Animal models, COGNITION, Gliosis, Neurodegeneration, Oxidative Stress, SAMP8, Tau phosphorylationAutores:Antoni Camins, Casadesús G., Chang J., Kim H.J., Lee H.g., Pallás M., Perry G., Smith M.A., Zhu X.Fuentes:scopusResveratrol and neurodegenerative diseases: Activation of SIRT1 as the potential pathway towards neuroprotection
ReviewAbstract: One of the current problems in medicine research is the development of safe drugs for the treatmentPalabras claves:Autores:Antoni Camins, Casadesús G., Coto-Montes A., Pallás M., Pelegrí Gabalda C., Smith M.A., Vilaplana J.Fuentes:scopusThe effect of mGluR2 activation on signal transduction pathways and neuronal cell survival
ArticleAbstract: In earlier studies, we found profound alterations in specific signal transduction pathways such as mPalabras claves:ERK, mGluR2, neuroprotectionAutores:Antoni Camins, Casadesús G., Lee H.g., Nakanishi S., O'Neill M.J., Pallás M., Perry G., Smith M.A., Zhu X.Fuentes:scopusThe sirtuin pathway in ageing and Alzheimer disease: Mechanistic and therapeutic considerations
OtherAbstract: Background: Advances in gerontology have yielded crucial insights into the molecular and biochemicalPalabras claves:Autores:Antoni Camins, Bonda D.J., Casadesús G., Lee H.g., Pallás M., Smith M.A., Zhu X.Fuentes:scopus