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Journal of Biological Chemistry(4)
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scopus(8)
15-Deoxy-Δ<sup>12,14</sup>-prostaglandin-J<inf>2</inf> reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1α degradation
ArticleAbstract: Hypoxia-inducible factor-1α (HIF-1α) protein is degraded under normoxia by its association to von HiPalabras claves:15-Deoxy-Δ -prostaglandin- J 12,14 2, Calpain, Heat shock protein-90, Hypoxia inducible factor, Lysosome, Proximal tubular cellsAutores:Aragonés J., Arenas M.I., Bienes R., Calzada M.J., Garcia-Bermejo M.L., Lucio-Cazaña J., Manuel Ortiz de Landázuri, Olmos G.Fuentes:scopusActivation of HIF-prolyl hydroxylases by R59949, an inhibitor of the diacylglycerol kinase
ArticleAbstract: Hypoxia-inducible factors (HIF) are heterodimeric (α/β) transcription factors that play a fundamentaPalabras claves:Autores:Acosta-Iborra B., Aragonés J., Castellanos M.C., Feijóo-Cuaresma M., Manuel Ortiz de Landázuri, Martin-Puig S., Olmos G., Temes E.Fuentes:scopusEvidence for the Involvement of Diacylglycerol Kinase in the Activation of Hypoxia-inducible Transcription Factor 1 by Low Oxygen Tension
ArticleAbstract: Hypoxia-inducible factor 1 (HIF-1) induces a gene expression program essential for the cellular adapPalabras claves:Autores:Alfranca A., Aragonés J., Jones D.R., Manuel Ortiz de Landázuri, Martin-Puig S., Mérida I., San Juan M.A., Vara A., Vidal F.Fuentes:scopusDithiocarbamates trigger differentiation and induction of CD11c gene through AP-1 in the myeloid lineage
ArticleAbstract: It has recently been shown that the alteration of the cell-redox status affects the transcription faPalabras claves:Autores:Aragonés J., Corbí A.L., Del Arco P.G., López-Cabrera M., López-Rodríguez C., Manuel Ortiz de Landázuri, Redondo J.M.Fuentes:scopusHIF2α Acts as an mTORC1 Activator through the Amino Acid Carrier SLC7A5
ArticleAbstract: The mammalian target of rapamycin (mTOR) pathway, which is essential for cell proliferation, is reprPalabras claves:Autores:Acosta-Iborra B., Albacete-Albacete L., Aragonés J., de Cárcer G., Elorza A., Giménez-Bachs J.M., Malumbres M., Manuel Ortiz de Landázuri, Marsboom G., Martín del Río R., Meléndez-Rodríguez F., Ordóñez A., Rodríguez-Vaello V., Salinas A., Sánchez-Prieto R., Sánchez‐Madrid F., Serrano-Oviedo L., Soro-Arnáiz I., Vara-Vega A.Fuentes:scopusInduction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting complex i activity
ArticleAbstract: The fine regulation of mitochondrial function has proved to be an essential metabolic adaptation toPalabras claves:Autores:Acosta-Iborra B., Aragonés J., Balsa E., Cadenas S., Corral-Escariz M., Elorza A., Enríquez J.A., Fuertes-Yebra E., López-Bernardo E., Manuel Ortiz de Landázuri, Martínez-Ruiz A., Ordóñez A., Perales-Clemente E., Soro I., Tello D.Fuentes:scopusRole of Iron (II)-2-Oxoglutarate-dependent Dioxygenases in the Generation of Hypoxia-induced Phosphatidic Acid through HIF-1/2 and von Hippel-Lindau-independent Mechanisms
ArticleAbstract: Hypoxia-inducible factors (HIF-1/HIF-2) govern the expression of critical genes for cellular adaptatPalabras claves:Autores:Aragonés J., Jones D.R., Manuel Ortiz de Landázuri, Martin-Puig S., Olmos G., Temes E.Fuentes:scopusRole of diacylglycerol induced by hypoxia in the regulation of HIF-1α activity
ArticleAbstract: Hypoxia-inducible factor 1 (HIF-1) is a critical transcription factor for the adaptation to loweredPalabras claves:Diacylglycerol, HIF-1, Hypoxia, Lipid second messengers, Phosphatidic acid, Protein regulation, signal transductionAutores:Aragonés J., Jones D.R., Manuel Ortiz de Landázuri, Martin-Puig S., Mérida I., Olmos G., Temes E.Fuentes:scopus