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15-Deoxy-Δ<sup>12,14</sup>-prostaglandin-J<inf>2</inf> reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1α degradation
ArticleAbstract: Hypoxia-inducible factor-1α (HIF-1α) protein is degraded under normoxia by its association to von HiPalabras claves:15-Deoxy-Δ -prostaglandin- J 12,14 2, Calpain, Heat shock protein-90, Hypoxia inducible factor, Lysosome, Proximal tubular cellsAutores:Aragonés J., Arenas M.I., Bienes R., Calzada M.J., Garcia-Bermejo M.L., Lucio-Cazaña J., Manuel Ortiz de Landázuri, Olmos G.Fuentes:scopusCD69 is a direct HIF-1α target gene in hypoxia as a mechanism enhancing expression on tumor-infiltrating T lymphocytes
ArticleAbstract: CD69 is an early activation marker on the surface of T lymphocytes undergoing activation by cognatePalabras claves:CD69, HIF-1α, Hypoxia, tumor microenvironment, tumor-infiltrating lymphocytes (TILs)Autores:Aragonés J., Aznar M.Á., Azpilikueta A., Bolaños E., de la Fuente H., Etxeberria I., Garasa S., Labiano S., Maiso P., Manuel Ortiz de Landázuri, Meléndez-Rodríguez F., Melero I., Molina C., Palazón A., Sánchez-Paulete A.R., Sánchez‐Madrid F., Teijeira A.Fuentes:scopusEvidence for the Involvement of Diacylglycerol Kinase in the Activation of Hypoxia-inducible Transcription Factor 1 by Low Oxygen Tension
ArticleAbstract: Hypoxia-inducible factor 1 (HIF-1) induces a gene expression program essential for the cellular adapPalabras claves:Autores:Alfranca A., Aragonés J., Jones D.R., Manuel Ortiz de Landázuri, Martin-Puig S., Mérida I., San Juan M.A., Vara A., Vidal F.Fuentes:scopusHIF2α Acts as an mTORC1 Activator through the Amino Acid Carrier SLC7A5
ArticleAbstract: The mammalian target of rapamycin (mTOR) pathway, which is essential for cell proliferation, is reprPalabras claves:Autores:Acosta-Iborra B., Albacete-Albacete L., Aragonés J., de Cárcer G., Elorza A., Giménez-Bachs J.M., Malumbres M., Manuel Ortiz de Landázuri, Marsboom G., Martín del Río R., Meléndez-Rodríguez F., Ordóñez A., Rodríguez-Vaello V., Salinas A., Sánchez-Prieto R., Sánchez‐Madrid F., Serrano-Oviedo L., Soro-Arnáiz I., Vara-Vega A.Fuentes:scopusInduction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting complex i activity
ArticleAbstract: The fine regulation of mitochondrial function has proved to be an essential metabolic adaptation toPalabras claves:Autores:Acosta-Iborra B., Aragonés J., Balsa E., Cadenas S., Corral-Escariz M., Elorza A., Enríquez J.A., Fuertes-Yebra E., López-Bernardo E., Manuel Ortiz de Landázuri, Martínez-Ruiz A., Ordóñez A., Perales-Clemente E., Soro I., Tello D.Fuentes:scopusUp-regulation of vascular endothelial growth factor receptor Flt-1 after endothelial denudation: Role of transcription factor Egr-1
ArticleAbstract: Vascular endothelial growth factor (VEGF) is highly expressed in vascular remodeling processes and aPalabras claves:Autores:Alfranca A., Aragonés J., Manuel Ortiz de Landázuri, Vidal F.Fuentes:scopusc-Jun and hypoxia-inducible factor 1 functionally cooperate in hypoxia-induced gene transcription
ArticleAbstract: Under low-oxygen conditions, cells develop an adaptive program that leads to the induction of severaPalabras claves:Autores:Alfranca A., Aragonés J., Gutiérrez M.D., Manuel Ortiz de Landázuri, Vara A., Vidal F.Fuentes:scopusPyrrolidine dithiocarbamate inhibits the production of interleukin-6, interleukin-8, and granulocyte-macrophage colony-stimulating factor by human endothelial cells in response to inflammatory mediators: Modulation of NF- κB and AP-1 transcription factors activity
ArticleAbstract: Endothelial cells (EC) play a key role in the inflammatory response, both by the production of proinPalabras claves:Autores:Alfranca A., Aragonés J., Castellanos M.D.C., Manuel Ortiz de Landázuri, Muñoz C., Pascual-Salcedo D., Redondo J.M., Vara A.Fuentes:scopus