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Article(5)
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PLoS ONE(2)
ACS Chemical Neuroscience(1)
Epilepsy and Behavior(1)
European Journal of Medicinal Chemistry(1)
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Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models
ArticleAbstract: Turmeric, obtained from the rhizomes of Curcuma longa, is used in South Asia as a traditional mediciPalabras claves:Ar-turmerone, Bisabolene sesquiterpenoids, curcuma longa, Mouse PTZ model, Pentylenetetrazole, Turmeric, turmeric oil, zebrafish PTZ model, α,β-Turmerone, α-AtlantoneAutores:Adriana Orellana-Paucar, Afrikanova T., Alen J., Crawford A.D., De Borggraeve W., De Witte P.A.M., Esguerra C.V., Fabián León-Tamariz, Maes J., Serruys A.S.K., Wilches IsabelFuentes:googlescopusDiscovery of novel anti-inflammatory drug-like compounds by aligning in silico and in vivo screening: The nitroindazolinone chemotype
ArticleAbstract: In this report, we propose the combination of computational methods and in vivo primary screening inPalabras claves:Anti-inflammatory compound, Anti-inflammatory database, Atom-based quadratic indices, Computational Screening, Cytotoxicity, In vivo anti-inflammatory assay, lead generation, Learning machine-based QSAR, ToMoCoMD-CARDD software, zebrafishAutores:Arán V.J., Crawford A.D., De Witte P.A.M., Esguerra C.V., Gálvez-Llompart M., García-Domnech R., Giner R.M., María Lorena Cordero-Maldonado, Recio M.C., Siverio-Mota D., Torrens F., Yovani Marrero-PonceFuentes:scopusInsights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy
ArticleAbstract: In a previous study, we uncovered the anticonvulsant properties of turmeric oil and its sesquiterpenPalabras claves:Autores:Adriana Orellana-Paucar, Afrikanova T., Aibuldinov Y.K., De Witte P.A.M., Dehaen W., Esguerra C.V., Thomas J.Fuentes:googlescopusIntegration of Microfractionation, qNMR and Zebrafish Screening for the In Vivo Bioassay-Guided Isolation and Quantitative Bioactivity Analysis of Natural Products
ArticleAbstract: Natural products (NPs) are an attractive source of chemical diversity for small-molecule drug discovPalabras claves:Autores:Bohni N., Crawford A.D., De Witte P.A.M., Esguerra C.V., Kamuhabwa A.R., Maes J., Marcourt L., María Lorena Cordero-Maldonado, Moshi M.J., Munck S., Siverio-Mota D., Wolfender J.L.Fuentes:rraaescopusTanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models
ArticleAbstract: Danshen or Chinese red sage (Salvia miltiorrhiza, Bunge) is used by traditional Chinese medicine (TCPalabras claves:mouse seizure models, pentylenetetrazol, Salvia miltiorrhiza, Tanshinone IIA, zebrafish PTZ modelAutores:Adriana Orellana-Paucar, Buenafe O.E., Crawford A.D., De Borggraeve W., De Witte P.A.M., Esguerra C.V., Huang H., Luyten W., Maes J., Ying X.Fuentes:googlescopus