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Discovery of novel anti-inflammatory drug-like compounds by aligning in silico and in vivo screening: The nitroindazolinone chemotype
ArticleAbstract: In this report, we propose the combination of computational methods and in vivo primary screening inPalabras claves:Anti-inflammatory compound, Anti-inflammatory database, Atom-based quadratic indices, Computational Screening, Cytotoxicity, In vivo anti-inflammatory assay, lead generation, Learning machine-based QSAR, ToMoCoMD-CARDD software, zebrafishAutores:Arán V.J., Crawford A.D., De Witte P.A.M., Esguerra C.V., Gálvez-Llompart M., García-Domnech R., Giner R.M., María Lorena Cordero-Maldonado, Recio M.C., Siverio-Mota D., Torrens F., Yovani Marrero-PonceFuentes:scopusNew insights into the early mechanisms of epileptogenesis in a zebrafish model of Dravet syndrome
ArticleAbstract: Objective: To pinpoint the earliest cellular defects underlying seizure onset (epileptogenic period)Palabras claves:Dravet syndrome, epileptogenesis, fenfluramine, Sodium channel, zebrafishAutores:Brattespe J., Esguerra C.V., Gawel K., Grzyb K., Heintz S., María Lorena Cordero-Maldonado, Martina S., Poovathingal S.K., Satheesh S.V., Skupin A., Suster M., Tiraboschi E., van der Ent W., Xu J.Fuentes:scopus