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Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo
ReviewAbstract: Signaling by the many ligands of the TGFβ family strongly converges towards only five receptor-activPalabras claves:CPSF, Sip1, Smad, Tdp2, Transforming growth factor βAutores:Beets K., Cazzola S., Coddens K., Collart C., Conidi A., Cornelis F.M., Cox L., Dobreva M.P., Dries R., Esguerra C.V., Francis A., Huylebroeck D., Ibrahimi A., Iván M. Moya, Joke D., Kroes R., Lesage F., Maas E., Pereira P.N.G., Seuntjens E., Stappers E., Stryjewska A., Umans L., van den Berghe V., Vermeire L., Verstappen G., Zwijsen A.Fuentes:googlescopusDiscovery of novel anti-inflammatory drug-like compounds by aligning in silico and in vivo screening: The nitroindazolinone chemotype
ArticleAbstract: In this report, we propose the combination of computational methods and in vivo primary screening inPalabras claves:Anti-inflammatory compound, Anti-inflammatory database, Atom-based quadratic indices, Computational Screening, Cytotoxicity, In vivo anti-inflammatory assay, lead generation, Learning machine-based QSAR, ToMoCoMD-CARDD software, zebrafishAutores:Arán V.J., Crawford A.D., De Witte P.A.M., Esguerra C.V., Gálvez-Llompart M., García-Domnech R., Giner R.M., María Lorena Cordero-Maldonado, Recio M.C., Siverio-Mota D., Torrens F., Yovani Marrero-PonceFuentes:scopus