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Analysis of HIF-prolyl hydroxylases binding to substrates
ArticleAbstract: Hypoxia inducible transcription factors (HIF) are mainly regulated by a group of proline hydroxylasePalabras claves:EGLN, HIF, Hypoxia, PhD, Proline-hydroxylation, VHLAutores:Cuevas Y., Manuel Ortiz de Landázuri, Peso L.D., Vara-Vega A., Vitón M.Fuentes:scopusHypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1
ArticleAbstract: When oxygen becomes limiting, cells reduce mitochondrial respiration and increase ATP production thrPalabras claves:Autores:Cifuentes D., Cuevas Y., Garcia-Bermejo M.L., Garcia-Rocha M., Guinovart J., Manuel Ortiz de Landázuri, Ordóñez A., Ortiz-Barahona A., Pescador N., Peso L.D., Saez-Morales D., Vazquez S.N., Villar D.Fuentes:scopusIdentification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene
ArticleAbstract: Low oxygen levels induce an adaptive response in cells through the activation of HIFs (hypoxia-inducPalabras claves:EGL nine homologous protein 3 (EGLN3), HIF proline hydroxylase 3 (HPH3), Hypoxia response element (HRE), Hypoxia-inducible factor (HIF), Proline hydroxylase domain 3 (PHD3), Prolyl hydroxylaseAutores:Alcaide M., Cuevas Y., Manuel Ortiz de Landázuri, Naranjo S., Pescador N., Peso L.D., Villar D.Fuentes:scopusSpecific Oncolytic Effect of a New Hypoxia-Inducible Factor-Dependent Replicative Adenovirus on von Hippel-Lindau-Defective Renal Cell Carcinomas
ArticleAbstract: Mutations in the von Hippel-Lindau (VHL) tumor suppressor gene are responsible for a hebkp_reditaryPalabras claves:Autores:Aragonés J., Castellanos M.C., Cuevas Y., Esteban M.A., Hernández-Alcoceba R., Manuel Ortiz de Landázuri, Martin-Puig S., Naranjo-Suárez S., Peso L.D.Fuentes:scopusThe von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen
ArticleAbstract: Most of the genes induced by hypoxia are regulated by a family of transcription factors termed hypoxPalabras claves:Autores:Castellanos M.C., Cuevas Y., Manuel Ortiz de Landázuri, Martin-Puig S., Olmos G., Peso L.D., Temes E.Fuentes:scopus