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Article(7)
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Journal of Biological Chemistry(2)
Journal of Steroid Biochemistry and Molecular Biology(2)
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scopus(7)
Catalytically relevant electrostatic interactions of cytochrome P450c17 (CYP17A1) and cytochrome b<inf>5</inf>
ArticleAbstract: Background: Cytochrome b5 (b5) stimulates the 17,20-lyase activity of cytochrome P450c17 (CYP17A1).Palabras claves:Autores:Anderson S.M., Forsberg S.E., Liu J., Peng H.M., Richard J. Auchus, Tran H.T.Fuentes:scopusFunctional characterization of the G162R and D216H genetic variants of human CYP17A1
ArticleAbstract: Cytochrome P450 17A1 (CYP17A1) is a dual-function enzyme catalyzing reactions necessary for cortisolPalabras claves:CYP17A1, Cytochrome p450, Proteasome, steroidogenesis, UbiquitinationAutores:Capper C.P., Hollenberg P.F., Johnson M.D., Larios J.M., Liu J., McIntosh L.R., Osawa Y., Rae J.M., Richard J. AuchusFuentes:scopusExpression in escherichia coli, purification, and functional reconstitution of human steroid 5α-reductases
ArticleAbstract: The potent androgen 5α-dihydrotestosterone irreversibly derives from testosterone via the activity oPalabras claves:5α-reductase, androgen, Dihydrotestosterone, prostate, steroidogenesisAutores:Han B., Im S.C., Liu J., Peng H.M., Qiao J., Richard J. Auchus, Valentín-Goyco J.Fuentes:scopusOpposing effects of cyclooxygenase-2 (COX-2) on estrogen receptor β (ERβ) response to 5α-reductase inhibition in prostate epithelial cells
ArticleAbstract: Current pharmacotherapies for symptomatic benign prostatic hyperplasia (BPH), an androgen receptor-dPalabras claves:Autores:DeFranco D.B., Frahm K.A., Grubisha M.J., Liu J., Liu T.T., Richard J. Auchus, Ricke W.A., Wendell S.G.Fuentes:scopusImpaired 17,20-lyase activity in male mice lacking cytochrome b<inf>5</inf> in leydig cells
ArticleAbstract: Androgen and estrogen biosynthesis in mammals requires the 17,20-lyase activity of cytochrome P450 1Palabras claves:Autores:Arlt W., Chomic R., Hughes B.A., Kliewer S.A., Liu J., Mangelsdorf D.J., Owen B.M., Richard J. Auchus, Sondhi V.Fuentes:scopusSelectivity of osilodrostat as an inhibitor of human steroidogenic cytochromes P450
ArticleAbstract: Osilodrostat (LCI699) is a potent inhibitor of the human steroidogenic cytochromes P450 11β-hydroxylPalabras claves:Cushing syndrome, Cytochrome p450, LCI699, Osilodrostat, steroidogenesisAutores:Liu J., Oommen J., Peng H.M., Richard J. Auchus, Valentín-Goyco J.Fuentes:scopusProfiles of 21-carbon steroids in 21-hydroxylase deficiency
ArticleAbstract: Context: Marked elevations of 17-hydroxyprogesterone (17OHP) are characteristic of classic 21-hydroxPalabras claves:Autores:Chomic R., Else T., Liu J., Moraitis A.G., Nishimoto H.K., Palapattu G.S., Rainey W.E., Rege J., Richard J. Auchus, Turcu A.F.Fuentes:scopus