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Bovine milk-derived exosomes as a drug delivery vehicle for mirna-based therapy
ArticleAbstract: MicroRNAs (miRNAs) are small non-coding RNAs with a known role as mediators of gene expression in crPalabras claves:Bovine milk, exosomes, Extracellular vesicles, miRNAs, Size exclusion chromatographyAutores:Almudena García-Ruiz, Busto R., Dávalos A., del Pozo-Acebo L., Gil-Cabrerizo P., López de Las Hazas M.C., San-Cristobal R., Tomé-Carneiro J.Fuentes:scopusDietary bovine milk miRNAs transported in extracellular vesicles are partially stable during GI digestion, are bioavailable and reach target tissues but need a minimum dose to impact on gene expression
ArticleAbstract: PURPOSE: Extracellular RNAs are unstable and rapidly degraded unless protected. Bovine-milk extracelPalabras claves:exosomes, Extracellular vesicles, in vitro digestion, Milk miRNAs, Transcriptome, TransfectionAutores:Almudena García-Ruiz, Dávalos A., del Pozo-Acebo L., Gil-Zamorano J., Gómez-Coronado D., Hansen M.S., López de Las Hazas M.C., Mantilla-Escalante D.C., Marín F., Rasmussen J.T.Fuentes:scopus