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A novel rhein-huprine hybrid ameliorates disease-modifying properties in preclinical mice model of Alzheimer’s disease exacerbated with high fat diet
ArticleAbstract: Background: Alzheimer’s disease (AD) is characterized by a polyetiological origin. Despite the globaPalabras claves:Alzheimer’s disease, BACE1, BDNF, cognitive decline, dendritic spines, high-fat diet, neuroinflammation, Rhein-huprine hybrid, Tau, TLR4Autores:Antoni Camins, Auladell C., Bulló M., Cano A., Espinosa-Jimenez T., Ettcheto M., Folch J., Muñoz-Torrero D., Olloquequi J., Parcerisas A., Pont C., Sanchez-Lopez E., Verdaguer E.Fuentes:scopusRole of c-jun N-terminal kinases (JNKs) in epilepsy and metabolic cognitive impairment
ReviewAbstract: Previous studies have reported that the regulatory function of the different c-Jun N-terminal kinasePalabras claves:BRAIN, C-Jun-N-terminal kinase, cognitive impairment, Epilepsy, JNK inhibitor, metabolism, Type 2 DiabetesAutores:Antoni Camins, Auladell C., Busquets O., Cano A., Castro-Torres R.D., Espinosa-Jimenez T., Ettcheto M., Folch J., Manzine P.R., Olloquequi J., Sanchez-Lopez E., Sureda F.X., Verdaguer E., Zárate C.B.Fuentes:scopus