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Characterization of amyloid-β granules in the hippocampus of SAMP8 mice
ArticleAbstract: The senescence accelerated mouse-prone 8 (SAMP8) strain of mice is an experimental model of acceleraPalabras claves:Alzheimer's disease, Amyloid-β, hippocampus, HSPG, MAP-2, SAMP8, syndecan, TauAutores:Antoni Camins, Del Valle J., Duran-Vilaregut J., Manich G., Mercader C., Pallás M., Vilaplana J.Fuentes:scopusClustered granules present in the hippocampus of aged mice result from a degenerative process affecting astrocytes and their surrounding neuropil
ArticleAbstract: Clusters of pathological granular structures appear and progressively increase in number with age inPalabras claves:aging, Astrocyte, Granules, hippocampus, Neo-epitope, Periodic acid-Schiff, SAMP8Autores:Antoni Camins, Cabezón I., Liberski P.P., Manich G., Pallás M., Pelegrí Gabalda C., Vilaplana J.Fuentes:scopusEarly amyloid accumulation in the hippocampus of SAMP8 mice
ArticleAbstract: Late-onset Alzheimer's disease (AD) is the most common form of AD appearing after 65 years of age. TPalabras claves:aging, Alzheimer's disease, Amyloid-β, Aβ40, Aβ42, AβPP, hippocampus, SAMP8, SAMR1, SenescenceAutores:Antoni Camins, Casadesús G., Del Valle J., Duran-Vilaregut J., Manich G., Pallás M., Pelegrí Gabalda C., Smith M.A., Vilaplana J.Fuentes:scopusStudy of the transcytosis of an anti-transferrin receptor antibody with a Fab′ cargo across the blood-brain barrier in mice
ArticleAbstract: One strategy used to transport pharmacologically active substances across the blood-brain barrier (BPalabras claves:8D3 antibody, blood-brain barrier, receptor-mediated transcytosis, Transferrin receptorAutores:Antoni Camins, Cabezón I., Del Valle J., Duran-Vilaregut J., Manich G., Pallás M., Pelegrí Gabalda C., Vilaplana J.Fuentes:scopusSystemic administration of 3-nitropropionic acid points out a different role for active caspase-3 in neurons and astrocytes
ArticleAbstract: The intraperitoneal administration of 3-nitropropionic acid, which is commonly used to induce toxiciPalabras claves:apoptosis, Huntington's disease, Neurodegeneration, RAT, Striatum, TUNELAutores:Antoni Camins, Del Valle J., Duran-Vilaregut J., Junyent F., Manich G., Pallás M., Pelegrí Gabalda C., Vilaplana J.Fuentes:scopusTime-course of blood-brain barrier disruption in senescence-accelerated mouse prone 8 (SAMP8) mice
ArticleAbstract: Senescence of the cerebrovascular system and an abnormal function of the blood-brain barrier have bePalabras claves:Alzheimer's disease, blood-brain barrier, Evans blue, SAMP8, SAMR1Autores:Antoni Camins, Del Valle J., Duran-Vilaregut J., Manich G., Pallás M., Pelegrí Gabalda C., Vilaplana J.Fuentes:scopusTrafficking of Gold Nanoparticles Coated with the 8D3 Anti-Transferrin Receptor Antibody at the Mouse Blood-Brain Barrier
ArticleAbstract: Receptor-mediated transcytosis has been widely studied as a possible strategy to transport neurotherPalabras claves:blood-brain barrier, drug delivery, Electron microscopy, monoclonal antibodies, receptor-mediated transport, Transferrin receptorAutores:Antoni Camins, Cabezón I., Manich G., Martín-Venegas R., Pelegrí Gabalda C., Vilaplana J.Fuentes:scopusRole of matrix metalloproteinase-9 (MMP-9) in striatal blood-brain barrier disruption in a 3-nitropropionic acid model of Huntington's disease
ArticleAbstract: Aim: 3-Nitropropionic acid (3-NPA) is a natural toxin that, when administered to experimental animalPalabras claves:3-nitropropionic acid, blood-brain barrier, Huntington's disease, Immunohistochemistry, Matrix metallopro teinase, StriatumAutores:Antoni Camins, Del Valle J., Duran-Vilaregut J., Manich G., Pallás M., Pelegrí Gabalda C., Vilaplana J.Fuentes:scopusPresence of a neo-epitope and absence of amyloid beta and tau protein in degenerative hippocampal granules of aged mice
ArticleAbstract: Clustered pathological granules related to a degenerative process appear and increase progressivelyPalabras claves:aging, hippocampus, Igm, Mouse ascites Golgi, Periodic acid-Schiff, SAMP8, β-AmyloidAutores:Antoni Camins, Cabezón I., Del Valle J., Manich G., Pallás M., Pelegrí Gabalda C., Vilaplana J.Fuentes:scopus