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Antikinetoplastid activity of indolocarbazoles from streptomyces sanyensis
ArticleAbstract: Chagas disease and leishmaniasis are neglected tropical diseases caused by kinetoplastid parasites oPalabras claves:Indolocarbazole, Kinetoplastid, Leishmanicidal, Streptomyces, TrypanocidalAutores:Bethencourt-Estrella C.J., Díaz-Marrero A.R., Javier Fernández J., L. Cartuche Flores, López-Arencibia A., Lorenzo-Morales J., Nicolás-Hernández D.S., Piñero J.E., Sifaoui I.Fuentes:scopusAntiprotozoan lead discovery by aligning dry and wet screening: Pbkp_rediction, synthesis, and biological assay of novel quinoxalinones
ArticleAbstract: Protozoan parasites have been one of the most significant public health problems for centuries and sPalabras claves:Antimalarial, Antiprotozoan database, Antitoxoplasma, antitrichomonas, Antitrypanosomal, classification model, Cytotoxicity, In silico study, In vitro assay, Leishmanicide, Machine learning-based QSAR, Non-stochastic and stochastic linear indices, ToMoCoMD-CARDD softwareAutores:Arán V.J., Cabrera-Serra M.G., Chicharro R., García-Domenech R., García-Sánchez R.N., García-Trevijano J.A.E., Gómez-Barrio A., Ibarra-Velarde F., López-Arencibia A., Lorenzo-Morales J., Machado-Tugores Y., Martín-Navarro C., Martínez-Fernández A.R., Martins Alho M.A., Meneses-Marcel A., Mondragón M., Mondragón R., Montero-Torres A., Nogal-Ruiz J.J., Pérez-Giménez F., Piñero J.E., Rivera N., Rolón M.S., Stephen Jones Barigye, Tytgat J., Vega M.C., Yovani Marrero-PonceFuentes:scopusStaurosporine from Streptomyces sanyensis activates Programmed Cell Death in Acanthamoeba via the mitochondrial pathway and presents low in vitro cytotoxicity levels in a macrophage cell line
ArticleAbstract: Recently, the search for novel therapeutic agents against Acanthamoeba species has been focused on tPalabras claves:Autores:Darío Cruz S, Díaz-Marrero A.R., Javier Fernández J., L. Cartuche Flores, López-Arencibia A., Lorenzo-Morales J., Piñero J.E., Reyes-Batlle M., Sifaoui I.Fuentes:scopus