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Defeating Leishmania resistance to Miltefosine (hexadecylphosphocholine) by peptide-mediated drug smuggling: A proof of mechanism for trypanosomatid chemotherapy
ArticleAbstract: Miltefosine (hexadecylphosphocholine, HePC), the first orally active drug successful against leishmaPalabras claves:cell-penetrating peptide, LEISHMANIA, Miltefosine, Resistance reversion, Tat, TrypanosomaAutores:Acuña A.U., Amat-Guerri F., Andreu D., B. G. De la Torre, Bart J.M., Hornillos V., Luque-Ortega J.R., Navarro M., Rivas L., Rueda C.Fuentes:scopusThe induction of NOS2 expression by the hybrid cecropin A-melittin antibiotic peptide CA(1-8)M(1-18) in the monocytic line RAW 264.7 is triggered by a temporary and reversible plasma membrane permeation
ArticleAbstract: There is an increasing awareness of immune cell modulation by antimicrobial peptides. While this proPalabras claves:Antimicrobial peptide, Cecropin A-melittin, electrophysiology, macrophageAutores:Andreu D., Arias C., B. G. De la Torre, Guerrero E., Guizy M., Luque-Ortega J.R., Rivas L., Valenzuela C.Fuentes:scopus