Cushing's Syndrome

Abstract:

The term 'Cushing's syndrome' refers to any state of glucocorticoid excess and its associated clinical manifestations. The most common cause is exogenous glucocorticoid administration, either as replacement therapy or for pharmacological actions, most commonly immunosuppression. Endogenous Cushing's syndrome can be either adrenocorticotropin (ACTH) dependent or independent. If ACTH dependent, the cause is most commonly a pituitary tumor secreting ACTH with impaired negative feedback from high circulating cortisol concentrations, or a neuroendocrine tumor producing ACTH ectopically. If ACTH independent, it is due to the autonomous function of one or both adrenal glands, including adrenal adenomas, adrenocortical carcinomas, and micronodular or macronodular hyperplasia. The clinical manifestations of Cushing's syndrome are protean and reflect the catabolic actions of cortisol on skin, muscle, bone, liver, and fat.

Año de publicación:

2014

Keywords:

• Hypercortisolism
• Adrenocorticotropin
• Adrenocortical carcinoma
• Macronodular adrenocortical hyperplasia
• Adrenal adenoma
• Micronodular adrenocortical hyperplasia
• Cushing's disease
• Glucocorticoid
• Cushing's syndrome

Fuente:

scopus