Cyclic amino acid linkers stabilizing key loops of brain derived neurotrophic factor

Abstract:

Based on β-turn-like BDNF loops 2 and 4, involved in receptor interaction, cyclic peptide replicas were designed, synthesized and tested. In addition to the native turn residues, the cyclic peptides include a linker unit between the N- and C-termini, selected by molecular modeling among various non-proteinogenic cyclic amino acids. NMR conformational studies showed that most of the cyclic peptides were able to adopt turn-like structures. Several of the analogues displayed significant inhibition of the BDNF-induced TrkB receptor phosphorylation, and hence could be useful templates for developing improved antagonists for this receptor. © 2011 Elsevier Ltd. All rights reserved.

Año de publicación:

2012

Keywords:

• BDNF
• Secondary peptide structure mimetics
• Peptides
• β-Turn
• Growth factors

Fuente:

scopus