Deregulation of the Notch pathway as a common road in viral carcinogenesis

Abstract:

The Notch pathway is a conserved signaling pathway and a form of direct cell‐cell communication related to many biological processes during development and adulthood. Deregulation of the Notch pathway is involved in many diseases, including cancer. Almost 20% of all cancer cases have an infectious etiology, with viruses responsible for at least 1.5 million new cancer cases per year. Seven groups of viruses have been classified as oncogenic: hepatitis B and C viruses (HBV and HCV respectively), Epstein‐Barr virus (EBV), Kaposi sarcoma‐associated herpesvirus (KSHV), human T lymphotropic virus (HTLV‐1), human papillomavirus (HPV), and Merkel cell polyomavirus (MCPyV). These viruses share the ability to manipulate a variety of cell pathways that are critical in proliferation and differentiation, leading to malignant transformation. Viral proteins interact directly or indirectly with different members of the …

Año de publicación:

2018

Keywords:

Fuente:

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