Determination of T CD4 and CD8 linphocytes in HIV positive children with antirretroviral therapy.

Abstract:

This study evaluates the levels of CD4 and CD8 in HIV positive children Zulia state as parameter of efficiency of antirretroviral treatments. 50 children Innocens Foundation ages 1-12 living with or affected by HIV were studied. The subpopulation CD4 and CD8 linphocytes decided by means of flow citometry and the antirreotroviral treatments given by triplicate. The analysis information realized means of the program SPSS Windows, version11, 0; 2.001, being significant everything p< 0, 05. None child managed to be inmunosuppressed, they met levels of CD4, CD8 y CD4/CD8 high, being demonstrated so they were answering to the therapy antirretroviral. The statistical analyses demonstrated that were no significant differences (p> 0, 05) between the levels of CD4, CD8 and CD4/CD8, and Tukey's test revealed that only treatments had significant differences (p< 0, 05) were: AZT+ 3TC+ Nelfinavir with 3TC+ Nelfinavir+ Abacavir and d4T+ Lopinavir/Ritonavir+ Abacavir. The linfocitos CD4 and CD8 demonstrated to be an index to guide the decisions on the individual treatment and to evaluate if the therapy anti VIH is effective or not.

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