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Determination of human papiloma and herpes simplex viruses and their possible relation to the presence and type of preinvasive lesions on the uterine cervix

Abstract:

Cervical cancer persists as a public health problem world wide. Among the most studied in fectious agents that have been associated with neoplasic processes are viruses, including herpes and papilloma. This research was carried out in order to determine the possible relation between infection with her pessim plex virus (HSV) and human papilloma virus (HPV) and the presence and type of pre- invasive cervical lesions. Sixty- five samples of cervical tissue with lesions and ten apparently healthy controls were selected from female patients for the detection of HSV and HPV. PCR and hybridization (HC2) methods were implemented for genotyping HPV. For HPV, 15.38% were positive while for HSV, 20.0%. There was one case of co-infection in a patient with a high grade intraepithelial lesion (HSIL), showing a significant difference between HPV- positive patients with HSIL compared to women with LSIL, low grade intraepithelial lesions. Most of the HSV positive cases were detected in patients with LSIL. A significant correlation was proved between the type of lesion and the presence of high and low risk HPV geno types.